TRIAMCINOLONE ACETONIDE 21-DIHYDROGEN PHOSPHATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H32FO9P
Molecular Weight	514.4776
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TRIAMCINOLONE ACETONIDE 21-DIHYDROGEN PHOSPHATE

Structure Search

SMILES

CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)COP(O)(O)=O

InChI

InChIKey=NXLTXRVPGUCAHF-JNQJZLCISA-N

InChI=1S/C24H32FO9P/c1-20(2)33-19-10-16-15-6-5-13-9-14(26)7-8-21(13,3)23(15,25)17(27)11-22(16,4)24(19,34-20)18(28)12-32-35(29,30)31/h7-9,15-17,19,27H,5-6,10-12H2,1-4H3,(H2,29,30,31)/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C24H32FO9P
Molecular Weight	514.4776
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17088419

Triamcinolone acetonide- 21-dihydrogen phosphate is the long-acting derivative of a synthetic glucocorticoid triamcinolone. Triamcinolone acetonide has eight times more potency than prednisolone. Triamcinolone acetonide- 21-dihydrogen phosphate used for intravenous injection. It is supposed to be hydrolyzed rapidly in the body to form the free corticoid alcohol.

Approval Year

PubMed

Title	Date	PubMed
Comparison of the hypothalamic-pituitary-adrenal axis susceptibility upon single-dose i.m. depot versus long-acting i.v. triamcinolone acetonide therapy: a direct pharmacokinetic correlation.	2006-11	17088419

Sample Use Guides

In Vivo Use Guide

Single injection - 0.2 mg/kg

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:56:38 GMT 2025` Edited by `admin` on `Mon Mar 31 17:56:38 GMT 2025`
Record UNII	A3XWK6919F
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRIAMCINOLONE ACETONIDE 21-DIHYDROGEN PHOSPHATE

Common Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 9-FLUORO-11-HYDROXY-16,17-((1-METHYLETHYLIDENE)BIS(OXY))-21-(PHOSPHONOOXY)-, (11.BETA.,16.ALPHA.)-

Preferred Name

English

TRIAMCINOLONE ACETONIDE 21-PHOSPHATE

Common Name

English

Code System Code Type Description

FDA UNII

A3XWK6919F