FITUSIRAN SODIUM

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 10:26:34 UTC 2023` Edited by `admin` on `Sat Dec 16 10:26:34 UTC 2023`
Nucleic Acid Subtype
Sequence Type	OLIGONUCLEOTIDE
Record UNII	A2PQ8BS44A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FITUSIRAN SODIUM

Official Name

English

RNA, ((2'-DEOXY-2'-FLUORO)G-SP-GM-SP-(2'-DEOXY-2'-FLUORO)U-UM-(2'-DEOXY-2'-FLUORO)A-AM-(2'-DEOXY-2'-FLUORO)C-AM-(2'-DEOXY-2'-FLUORO)C-(2'-DEOXY-2'-FLUORO)C-(2'-DEOXY-2'-FLUORO)A-UM-(2'-DEOXY-2'-FLUORO)U-UM-(2'-DEOXY-2'-FLUORO)A-CM-(2'-DEOXY-2'-FLUORO)U-U

Common Name

English

FITUSIRAN SODIUM [JAN]

Common Name

English

ALN-57213 SODIUM

Common Name

English

ALN-AT3SC SODIUM [JAN]

Common Name

English

Code System Code Type Description

FDA UNII

A2PQ8BS44A

Created by admin on Sat Dec 16 10:26:34 UTC 2023 , Edited by admin on Sat Dec 16 10:26:34 UTC 2023

PRIMARY

Sugar	Site Range	Site Count
2'-Fluoro-Ribose	1_1;1_3;1_5;1_7;1_9-1_11;1_13;1_15;1_17;1_19;1_21;2_2;2_4;2_6;2_8;2_10;2_14;2_16;2_18;2_20	21 / 45
2'-O-Methyl-Ribose	1_2;1_4;1_6;1_8;1_12;1_14;1_16;1_18;1_20;1_22;2_1;2_3;2_5;2_7;2_9;2_11-2_13;2_15;2_17;2_19;2_21-2_23	24 / 45

Linkage	Site Range	Site Count
Sodium Phosporothioate	1_2-1_3;2_2-2_3;2_22-2_23	6 / 43
	1_4-1_22;2_4-2_21	37 / 43

Related Record Type Details


					SV9W47ZLE1

FITUSIRAN

PARENT -> SALT/SOLVATE

Amount:

Related Record Type Details


					SV9W47ZLE1

FITUSIRAN

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_22]		X		GIVOSIRAN SODIUM TRIGLYCAN-END GROUP	8142CN1H73

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL