Nebratamig

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 16:57:33 GMT 2025` Edited by `admin` on `Wed Apr 02 16:57:33 GMT 2025`
Protein Type	TETRASPECIFIC ANTIBODY
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	A2B6R66VSJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Nebratamig

Official Name

English

Immunoglobulin, anti-(human tumor necrosis factor receptor TNFRSF9) (human-Oryctolagus cuniculus clone 420H5 single-chain Fv fragment VL-(GGGGS)4-VH) fusion protein with peptide linker (GGGGS)2 fusion protein with immunoglobulin G1 [232-alanine,233-alani

Preferred Name

English

nebratamig [INN]

Common Name

English

immunoglobulin scFv-G1-scFv-scFv_L-kappa, anti-[Homo sapiens TNFRSF9 (TNF receptor superfamily member 9, 4-1BB, ILA, CD137)], anti-[Homo sapiens CD274 (programmed cell death 1 ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, PDCD1LG1)], anti-[Homo sapie

Common Name

English

Code System Code Type Description

SMS_ID

300000051845

Created by admin on Wed Apr 02 16:57:33 GMT 2025 , Edited by admin on Wed Apr 02 16:57:33 GMT 2025

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CAS

2694723-68-5

Created by admin on Wed Apr 02 16:57:33 GMT 2025 , Edited by admin on Wed Apr 02 16:57:33 GMT 2025

PRIMARY

INN

12499

Created by admin on Wed Apr 02 16:57:33 GMT 2025 , Edited by admin on Wed Apr 02 16:57:33 GMT 2025

PRIMARY

NCI_THESAURUS

C183545

Created by admin on Wed Apr 02 16:57:33 GMT 2025 , Edited by admin on Wed Apr 02 16:57:33 GMT 2025

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FDA UNII

A2B6R66VSJ

Created by admin on Wed Apr 02 16:57:33 GMT 2025 , Edited by admin on Wed Apr 02 16:57:33 GMT 2025

PRIMARY

From	To
4_137	4_197
4_23	4_88
3_137	3_197
3_23	3_88
2_474	4_217
1_483	2_483
1_480	2_480
1_474	3_217
1_1070	1_1138
2_1070	2_1138
1_997	1_1070
2_997	2_1070
1_875	1_942
2_875	2_942
1_732	1_806
2_732	2_806
1_621	1_679
2_621	2_679
1_515	1_575
2_515	2_575
1_398	1_454
2_398	2_454
1_277	1_350
2_277	2_350
1_152	1_225
2_152	2_225
1_23	1_88
2_23	2_88

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_551
N	2_551

Related Record Type Details


					ZLW14X2D30

CD3

TARGET->LIGAND

Comments:

CD3 delta

Amount:


					L4766ELH5T

PROGRAMMED CELL DEATH 1 LIGAND 1

TARGET->LIGAND

Amount:


					KJK2T89UWP

INACTIVE TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR1

TARGET->LIGAND

Amount:


					7VWM3OLK0G

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 9

TARGET->LIGAND

Amount:

Related Record Type Details


					A2B6R66VSJ

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL