TEMAROTENE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H28
Molecular Weight	304.4684
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C\C(=C/C1=CC=CC=C1)C2=CC=C3C(=C2)C(C)(C)CCC3(C)C

InChI

InChIKey=MUJQTAMVZYFLCR-BMRADRMJSA-N

InChI=1S/C23H28/c1-17(15-18-9-7-6-8-10-18)19-11-12-20-21(16-19)23(4,5)14-13-22(20,2)3/h6-12,15-16H,13-14H2,1-5H3/b17-15+

HIDE SMILES / InChI

Molecular Formula	C23H28
Molecular Weight	304.4684
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3138121

Temarotene (also known as Ro 15-0778), the arotinoid with immunosuppressive and immunostimulatory activities. Temarotene was also studied as a chemopreventive agent. Information about the current development of this compound is not available.

Approval Year

PubMed

Title	Date	PubMed
Retinoids inhibit human epidermal keratinocyte RNase P activity.	2003-03	12715896
Concentration of temarotene (Ro 15-0778) and its metabolite Ro 14-6113 in plasma and skin of hairless rat.	1993	8489777
Modulation of human immune functions in vitro by temarotene and its metabolite.	1991	1837465
Treatment of lichen planus with temarotene.	1989-10-21	2571878
Therapeutic effect of the arotinoid Ro 15-0778 on chemically induced rat mammary carcinoma.	1988-07	3138121

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:24:09 GMT 2025` Edited by `admin` on `Wed Apr 02 09:24:09 GMT 2025`
Record UNII	A28G39IJ7K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TEMAROTENE

Official Name

English

RO 15-0778

Preferred Name

English

temarotene [INN]

Common Name

English

1,2,3,4-TETRAHYDRO-1,1,4,4-TETRAMETHYL-6-((E)-.ALPHA.-METHYLSTYRYL)NAPHTHALENE

Systematic Name

English

RO-150788

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C804