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Details

Stereochemistry ABSOLUTE
Molecular Formula C43H63NO11
Molecular Weight 769.9604
Optical Activity UNSPECIFIED
Defined Stereocenters 14 / 14
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of SELAMECTIN

SMILES

[H][C@@]12OC\C3=C/C=C/[C@H](C)[C@H](O[C@@]4([H])C[C@H](OC)[C@@H](O)[C@H](C)O4)\C(C)=C\C[C@@H]5C[C@@H](C[C@]6(CC[C@H](C)[C@H](O6)C7CCCCC7)O5)OC(=O)[C@]([H])(C=C(C)\C1=N\O)[C@@]23O

InChI

InChIKey=AFJYYKSVHJGXSN-XHKIUTQPSA-N
InChI=1S/C43H63NO11/c1-24-11-10-14-30-23-50-40-36(44-48)27(4)19-33(43(30,40)47)41(46)52-32-20-31(16-15-25(2)38(24)53-35-21-34(49-6)37(45)28(5)51-35)54-42(22-32)18-17-26(3)39(55-42)29-12-8-7-9-13-29/h10-11,14-15,19,24,26,28-29,31-35,37-40,45,47-48H,7-9,12-13,16-18,20-23H2,1-6H3/b11-10+,25-15+,30-14+,44-36-/t24-,26-,28-,31+,32-,33-,34-,35-,37-,38-,39-,40+,42+,43+/m0/s1

HIDE SMILES / InChI

Molecular Formula C43H63NO11
Molecular Weight 769.9604
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 14 / 14
E/Z Centers 1
Optical Activity UNSPECIFIED

Description

Selamectin (trade name Revolution, Stronghold) is a broad-spectrum endectocide. It is used in dogs and cats for treatment, control and prevention against fleas, heartworms, ear mites, ticks and other parasites. Selamectin is not approved for human use. It is a a semi-synthetic compound of the avermectin class, a macrocyclic lactone.

CNS Activity

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
The recommended minimum dose for cats and dogs of six weeks of age and older is 2.7 mg selamectin per pound (6 mg/kg) of body weight as a single dose.
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
A2669OWX9N
Record Status Validated (UNII)
Record Version