SELAMECTIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C43H63NO11
Molecular Weight	769.9604
Optical Activity	UNSPECIFIED
Defined Stereocenters	14 / 14
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12OC\C3=C/C=C/[C@H](C)[C@H](O[C@@]4([H])C[C@H](OC)[C@@H](O)[C@H](C)O4)\C(C)=C\C[C@@H]5C[C@@H](C[C@]6(CC[C@H](C)[C@H](O6)C7CCCCC7)O5)OC(=O)[C@]([H])(C=C(C)\C1=N\O)[C@@]23O

InChI

InChIKey=AFJYYKSVHJGXSN-XHKIUTQPSA-N

InChI=1S/C43H63NO11/c1-24-11-10-14-30-23-50-40-36(44-48)27(4)19-33(43(30,40)47)41(46)52-32-20-31(16-15-25(2)38(24)53-35-21-34(49-6)37(45)28(5)51-35)54-42(22-32)18-17-26(3)39(55-42)29-12-8-7-9-13-29/h10-11,14-15,19,24,26,28-29,31-35,37-40,45,47-48H,7-9,12-13,16-18,20-23H2,1-6H3/b11-10+,25-15+,30-14+,44-36-/t24-,26-,28-,31+,32-,33-,34-,35-,37-,38-,39-,40+,42+,43+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C43H63NO11
Molecular Weight	769.9604
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	14 / 14
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: http://www.fda.gov/downloads/animalveterinary/products/approvedanimaldrugproducts/foiadrugsummaries/ucm117201.pdf
Curator's Comment: Description was created using several sources including: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8032a1ae-d192-4514-80f1-9a3b50dc2155; http://www.wipo.int/research/en/details.jsp?id=1502; https://www.zoetis.co.za/_locale-assets/pdf/revolution.pdf; http://www.ncbi.nlm.nih.gov/pubmed/19032763

Selamectin (trade name Revolution, Stronghold) is a broad-spectrum endectocide. It is used in dogs and cats for treatment, control and prevention against fleas, heartworms, ear mites, ticks and other parasites. Selamectin is not approved for human use. It is a a semi-synthetic compound of the avermectin class, a macrocyclic lactone.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Multimodal approach to treatment for control of fur mites.	2006 Jul	16884176
Interaction of macrocyclic lactones with P-glycoprotein: structure-affinity relationship.	2007 Jan	17134887
Brain penetration of ivermectin and selamectin in mdr1a,b P-glycoprotein- and bcrp- deficient knockout mice.	2009 Feb	19161460

Patents

Sample Use Guides

In Vivo Use Guide

The recommended minimum dose for cats and dogs of six weeks of age and older is 2.7 mg selamectin per pound (6 mg/kg) of body weight as a single dose.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:57:54 GMT 2023` Edited by `admin` on `Fri Dec 15 15:57:54 GMT 2023`
Record UNII	A2669OWX9N
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SELAMECTIN

Official Name

English

SELAMECTIN [EMA EPAR VETERINARY]

Common Name

English

SELAMECTIN COMPONENT OF STRONGHOLD PLUS

Brand Name

English

AVERMECTIN A1A, 25-CYCLOHEXYL-4'-O-DE(2,6-DIDEOXY-3-O-METHYL-.ALPHA.-L-ARABINO-HEXOPYRANOSYL)-5-DEMETHOXY-25-DE(1-METHYLPROPYL)-22,23-DIHYDRO-5(HYDROXYIMINO)-, (5Z)-

Common Name

English

SELAMECTIN [MART.]

Common Name

English

REVOLUTION

Brand Name

English

UK-124114

Code

English

SELAMECTIN [MI]

Common Name

English

SELAMECTIN [USP-RS]

Common Name

English

SELAMECTIN [GREEN BOOK]

Common Name

English

SELAMECTIN COMPONENT OF STRONGHOLD

Common Name

English

AVERMECTIN A1A, 25-CYCLOHEXYL-4'-O-DE(2,6-DIDEOXY-3-O-METHYL-.ALPHA.-L-ARABINO-HEXOPYRANOSYL)-5-DEMETHOXY-25-DE(1-METHYLPROPYL)-22,23-DIHYDRO-5-(HYDROXYIMINO)-

Common Name

English

selamectin [INN]

Common Name

English

SELAMECTIN [USAN]

Common Name

English

STRONGHOLD PLUS COMPONENT SELAMECTIN

Brand Name

English

UK-124,114

Code

English

SELAMECTIN [USP MONOGRAPH]

Common Name

English

STRONGHOLD COMPONENT SELAMECTIN

Brand Name

English

Classification Tree Code System Code

EMA VETERINARY ASSESSMENT REPORTS

STRONGHOLD [AUTHORIZED ]