BUTEDRONATE TETRASODIUM

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C5H6O10P2.4Na
Molecular Weight	380.0017
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].[Na+].[Na+].OP([O-])(=O)C(C(CC([O-])=O)C([O-])=O)P(O)([O-])=O

InChI

InChIKey=WQVCHXLTSYVIPX-UHFFFAOYSA-J

InChI=1S/C5H10O10P2.4Na/c6-3(7)1-2(4(8)9)5(16(10,11)12)17(13,14)15;;;;/h2,5H,1H2,(H,6,7)(H,8,9)(H2,10,11,12)(H2,13,14,15);;;;/q;4*+1/p-4

HIDE SMILES / InChI

Molecular Formula	C5H6O10P2
Molecular Weight	288.0427
Charge	-4
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugfuture.com/chemdata/butedronic-acid.html | DOI: 10.1038/clpt.1988.41 | (2013) Pharmeceutical manufacturing encyclopedia, page 753, retrieved from: https://books.google.ru/books?id=_J2ti4EkYpkC

Butedronic acid is used for diagnostic purposes. Tetrasodium salt of butedronic acid is bone imaging agent.

Approval Year

PubMed

Title	Date	PubMed
The assessment of bee venom responses in an experimental model of mono-arthritis using Tc-99m DPD bone scintigraphy.	2010-07	20379856
[Diagnosis of senile cardiac amyloidosis by (99m)Tc-DPD scintigraphy].	2009-04	18922670
[Nuclear medical imaging in case of painful knee arthroplasty].	2009-01	18597065
[Detection of bone metastasis of prostate cancer - comparison of whole-body MRI and bone scintigraphy].	2008-08	18512192
Usefulness of 99mTc-DPD scintigraphy in cardiac amyloidosis.	2008-04-15	18402909
Labeling, characterization, and in vivo localization of a new 90Y-based phosphonate chelate 2,3-dicarboxypropane-1,1-diphosphonic acid for the treatment of bone metastases: Comparison with 99mTc-DPD complex.	2008-04-15	18331797
[Transient osteoporosis of the hip in pregnancy. Successful treatment with calcitonin: a case report].	2007-10	17849129
Bone scintigraphy as a prognostic indicator for bone collapse in the early phases of femoral head osteonecrosis.	2007-06	17561588
Gastric accumulation of bone seeking agent in a patient with advanced gastric cancer.	2007-02	17297271
Puzzling intestinal uptake in 99mTc-DPD bone scintigraphy.	2006	16969952
Noninvasive etiologic diagnosis of cardiac amyloidosis using 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy.	2005-09-20	16168294
Comparison of the effect of 99mTc-DPD and 99mTc-MDP on experimentally-induced osteoarthritis in the stifle joint of the dog.	2005-07-08	15999549
Alteration of the organ uptake of the (99m)Tc-radiopharmaceuticals, (99m)Tc-DPD, (99m)Tc-DMSA, (99m)Tc-tin colloid and (99m)Tc-MAA, induced by the applied cytotoxic drugs methotrexate sodium and cyclophosphamide.	2005-05	15838423
Whole body bone scintigraphy after parachute accident.	2005-02	15847191
Tc-99m DPD uptake in the thigh from metastasis of adenocarcinoma of the rectum.	2005-01	15604976
Assessment of aseptic loosening of the acetabular component in a total hip replacement with 99mTc-DPD-SPECT/spiral-CT hybrid imaging.	2005	16408361
[TierSPECT: performance of a dedicated small-animal-SPECT camera and first in vivo measurements].	2005	15830780
Bone lesion detection with carrier-added 99mTc-EDTMP in comparison with 99mTc-DPD.	2004-04	15097810
Chemical and biological evaluation of technetium (I) tricarbonyl complexes with EHIDA and DPD. 99m (I) complexes of EHIDA and DPD.	2004	15318303
Unusual bilateral Tc-99m DPD uptake on bone scan.	2003-11	14578714
[Stress fracture of the sacrum in a professional basketball athlete].	2003-04	12677517
Bone scintigraphy using Tc-99m DPD and F18-FDG in a patient with SAPHO syndrome.	2003	12635949
Monostotic Paget's Disease of a cervical vertebra: differential diagnosis with F-18 FDG positron emission tomography using a coincidence technique and with Tc-99m dicarboxypropane diphosphonate.	2002-07	12072790
99mTc-DPD scintigraphy in transthyretin-related familial amyloidotic polyneuropathy.	2002-03	12002714
Bone pain with scintigraphy suggestive of widespread metastases--do not forget phosphate.	2002-03	11865102
Bone infarction resulting from parosteal soft tissue angiosarcoma.	2002-01	11805489
Skeletal scintigraphy in acquired adult Fanconi syndrome.	2002-01	11805488

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:26:37 GMT 2025` Edited by `admin` on `Mon Mar 31 18:26:37 GMT 2025`
Record UNII	A200DNE4C6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BUTEDRONATE TETRASODIUM

Official Name

English

BUTEDRONIC ACID TETRASODIUM SALT

Preferred Name

English

TC-924 (DPD)

Code

English

(±)-(DIPHOSPHONOMETHYL)SUCCINIC ACID, TETRASODIUM SALT

Common Name

English

BUTEDRONIC ACID TETRASODIUM SALT [MI]

Common Name

English

Butedronate tetrasodium [WHO-DD]

Common Name

English

BUTEDRONATE

Common Name

English

BUTEDRONATE TETRASODIUM [USAN]

Common Name

English

TC-924 DPD

Code

English

TECEOS

Brand Name

English

BUTANEDIOIC ACID, (DIPHOSPHONOMETHYL)-, TETRASODIUM SALT, (±)-

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C443