U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry UNKNOWN
Molecular Formula C20H17ClN2O3
Molecular Weight 368.814
Optical Activity ( - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of KETAZOLAM, (-)-

SMILES

CN1C2=CC=C(Cl)C=C2C3(OC(C)=CC(=O)N3CC1=O)C4=CC=CC=C4

InChI

InChIKey=PWAJCNITSBZRBL-UHFFFAOYSA-N
InChI=1S/C20H17ClN2O3/c1-13-10-18(24)23-12-19(25)22(2)17-9-8-15(21)11-16(17)20(23,26-13)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3

HIDE SMILES / InChI
Molecular Formula C20H17ClN2O3
Molecular Weight 368.814
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

KETAZOLAM, a benzodiazepine with an additional d-face-fused heterocyclic ring, possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is used for the treatment of anxiety and spasticity.

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
Ketazolam.
2001-07
Ketazolam and diazepam in anxiety: a controlled study.
1980-10
Anxiolytic efficacy and safety of ketazolam compared with diazepam and placebo.
1980
Double-blind placebo-controlled efficacy study of ketazolam (U-28,774).
1976
Substance Class Chemical
Created
by admin
on Mon Mar 31 23:38:41 GMT 2025
Edited
by admin
on Mon Mar 31 23:38:41 GMT 2025
Record UNII
9ZBH5G9835
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
(-)-KETAZOLAM
Preferred Name English
KETAZOLAM, (-)-
Common Name English
4H-(1,3)OXAZINO(3,2-D)(1,4)BENZODIAZEPINE-4,7(6H)-DIONE, 11-CHLORO-8,12B-DIHYDRO-2,8-DIMETHYL-12B-PHENYL-, (-)-
Systematic Name English
Code System Code Type Description
FDA UNII
9ZBH5G9835
Created by admin on Mon Mar 31 23:38:41 GMT 2025 , Edited by admin on Mon Mar 31 23:38:41 GMT 2025
PRIMARY
CAS
106939-00-8
Created by admin on Mon Mar 31 23:38:41 GMT 2025 , Edited by admin on Mon Mar 31 23:38:41 GMT 2025
PRIMARY
Related Record Type Details
Structure of KETAZOLAM, (+)-
ENANTIOMER -> ENANTIOMER
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966