SODIUM TETRACHLOROALUMINATE

US Approved OTC

Details

Stereochemistry	ACHIRAL
Molecular Formula	Al.4Cl.Na
Molecular Weight	191.783
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of SODIUM TETRACHLOROALUMINATE

Structure Search

SMILES

[Na+].[Al+3].[Cl-].[Cl-].[Cl-].[Cl-]

InChI

InChIKey=CMLRNXGMTZKKSR-UHFFFAOYSA-J

InChI=1S/Al.4ClH.Na/h;4*1H;/q+3;;;;;+1/p-4

HIDE SMILES / InChI

Molecular Formula	Al
Molecular Weight	26.9815
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.domeboro.com/about-domeboro/
Curator's Comment: Description was created based on several sources, including https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html

Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate. The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cell membrane 42 Target ID: CHEMBL2364031 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22718290 \| https://www.ncbi.nlm.nih.gov/pubmed/10211213	Interacts 323
vasoconstriction 32 Target ID: GO:0042310 Sources: https://www.drugs.com/monograph/aluminum-acetate.html	Activator 1430

Conditions

Condition	Modality	Targets	Highest Phase	Product
Itching 54 Sources: http://www.domeboro.com/about-domeboro/ https://www.drugs.com/monograph/aluminum-acetate.html	Primary		Approved 8429	DOMEBORO Approved Use Temporarily relieves minor skin irritations due to: – Poison ivy \| – Poison oak – Poison sumac \| – Insect bites – Athlete’s foot \| – Rashes caused by soaps, detergents, cosmetics, or jewelry
Otitis 40 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15516810 https://www.ncbi.nlm.nih.gov/pubmed/14724484 https://www.drugs.com/monograph/aluminum-acetate.html	Curative		Approved 8429	DOMEBORO Approved Use This medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection.

PubMed

Title	Date	PubMed
Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study.	1999 May	10327022
Aluminum inclusion macrophagic myofasciitis: a recently identified condition.	2003 Nov	14753387
Parenteral nutrition-associated cholestasis in neonates: the role of aluminum.	2003 Sep	14552065
The giant protein HERC1 is recruited to aluminum fluoride-induced actin-rich surface protrusions in HeLa cells.	2004 Feb 13	14960311
Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases.	2005 Nov	16308486
Aluminum and Alzheimer's disease, a personal perspective after 25 years.	2006	17004365
An effector domain mutant of Arf6 implicates phospholipase D in endosomal membrane recycling.	2006 Jan	16280360
Neurological adverse events of immunization: experience with an aluminum adjuvanted meningococcal B outer membrane vesicle vaccine.	2007 Oct	17931164
Ablative laser resurfacing: high-energy pulsed carbon dioxide and erbium:yttrium-aluminum-garnet.	2007 Sep-Oct	17870524
Altered glucose homeostasis in response to aluminium phosphide induced cellular oxygen deficit in rat.	2010 Jul	20929055

Patents

Sample Use Guides

In Vivo Use Guide

DOMEBORO® SOOTHING SOAK – dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water – stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use For use as a soak: – soak affected area for 15 to 30 minutes as needed, or as directed by a doctor – repeat 3 times a day or as directed by a doctor – discard solution after each use. For use as a compress or wet dressing: – soak a clean, soft cloth in the solution. – apply cloth loosely to affected area for 15 to 30 minutes – repeat as needed or as directed by a doctor – discard solution after each use

Route of Administration: Topical

In Vitro Use Guide

Burow's solution (13% aluminum subacetate) is active against S. aureus and P. aeruginosa, resulting in damage to the cell wall.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 04:14:36 GMT 2023` Edited by `admin` on `Sat Dec 16 04:14:36 GMT 2023`
Record UNII	9Z6200GDQZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SODIUM TETRACHLOROALUMINATE

Common Name

English

ALUMINATE(1-), TETRACHLORO-, SODIUM (1:1), (T-4)-

Systematic Name

English

ALUMINUM SODIUM CHLORIDE (ALNACL4)

Common Name

English

SODIUM ALUMINUM CHLORIDE (NAALCL4)

Common Name

English

ALUMINATE(1-), TETRACHLORO-, SODIUM

Systematic Name

English

SODIUM CHLOROALUMINATE

Common Name

English

SODIUM TETRACHLOROALUMINATE [MI]

Common Name

English

Code System Code Type Description

PUBCHEM

16699350