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Details

Stereochemistry ACHIRAL
Molecular Formula C5H6O5.C4H9N3O2
Molecular Weight 277.2313
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CREATINE ALPHA-KETOGLUTARATE

SMILES

CN(CC(O)=O)C(N)=N.OC(=O)CCC(=O)C(O)=O

InChI

InChIKey=VSQHMIFYITYXRG-UHFFFAOYSA-N
InChI=1S/C5H6O5.C4H9N3O2/c6-3(5(9)10)1-2-4(7)8;1-7(4(5)6)2-3(8)9/h1-2H2,(H,7,8)(H,9,10);2H2,1H3,(H3,5,6)(H,8,9)

HIDE SMILES / InChI

Molecular Formula C5H6O5
Molecular Weight 146.0981
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C4H9N3O2
Molecular Weight 131.1332
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Creatine is an amino acid that occurs in vertebrate tissues and in urine. It is synthesized mainly in the liver from three different amino acids: arginine, glycine, and methionine. In skeletal muscles, which store 95% of it, creatine generally occurs as phosphocreatine. The rest is stored in the brain, heart, and testes. Creatine functions as part of the cell's energy shuttle. It is excreted as creatinine in the urine.

Approval Year

PubMed

PubMed

TitleDatePubMed
Interstitial nephritis in a patient taking creatine.
1999 Mar 11
A dimeric creatine kinase from a sponge: implications in terms of phosphagen kinase evolution.
2000 May
Thrombectomy with the X-SIZER catheter system in the coronary circulation: initial results from a multi-center study.
2001 Feb
A controlled trial of topical nitroglycerin in a New Zealand white rabbit model of brown recluse spider envenomation.
2001 Feb
The three-dimensional structure of cytosolic bovine retinal creatine kinase.
2001 Feb
Uremic concentrations of guanidino compounds inhibit neutrophil superoxide production.
2001 Feb
Benefits of micronised Fenofibrate in type 2 diabetes mellitus subjects with good glycemic control.
2001 Feb 1
Structure of an intermediate in the unfolding of creatine kinase.
2001 Feb 1
Antisense inhibition of decorin expression in myoblasts decreases cell responsiveness to transforming growth factor beta and accelerates skeletal muscle differentiation.
2001 Feb 2
Rhabdomyolysis secondary to a drug interaction between simvastatin and clarithromycin.
2001 Jan
Creatine supplementation affects muscle creatine during energy restriction.
2001 Jan
Treatment of exercise-induced muscle injury via hyperbaric oxygen therapy.
2001 Jan
Oxygen free radical generation in healthy blood donors and cardiac patients: the protective effect of allopurinol.
2001 Jan
Leukocyte filtration in the early reperfusion phase on cardiopulmonary bypass reduces myocardial injury.
2001 Jan
Clinical, electrocardiographic, and biochemical data for immediate risk stratification in acute coronary syndromes.
2001 Jan
Improving diagnostic yield in brain biopsy: coupling spectroscopic targeting with real-time needle placement.
2001 Jan
Plasma lipids and urinary albumin excretion rate in Type 1 diabetes mellitus: the EURODIAB IDDM Complications Study.
2001 Jan
Systemic effects of hyperthermic isolated lower limb perfusion with carboplatin and interferon-beta.
2001 Jan
Mild phenotype of nemaline myopathy with sleep hypoventilation due to a mutation in the skeletal muscle alpha-actin (ACTA1) gene.
2001 Jan
Pretreatment of human myocardium with adenosine.
2001 Jan
Validation of NACB and IFCC guidelines for the use of cardiac markers for early diagnosis and risk assessment in patients with acute coronary syndromes.
2001 Jan
Apparent diffusion coefficients in the evaluation of high-grade cerebral gliomas.
2001 Jan
Transient QT interval prolongation with inverted T waves indicates myocardial salvage on dual radionuclide single-photon emission computed tomography in acute anterior myocardial infarction.
2001 Jan
Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization.
2001 Jan
Electrocardiographic exercise stress testing for cardiac risk assessment in patients undergoing noncardiac surgery.
2001 Jan
Ischemic preconditioning with opening of mitochondrial adenosine triphosphate-sensitive potassium channels or Na/H exchange inhibition: which is the best protective strategy for heart transplants?
2001 Jan
Mutations in the hepatocyte nuclear factor-1beta gene are associated with familial hypoplastic glomerulocystic kidney disease.
2001 Jan
An autopsy case of neuroleptic malignant syndrome (NMS) and its immunohistochemical findings of muscle-associated proteins and mitochondria.
2001 Jan 1
Muscle-specific promoters may be necessary for adeno-associated virus-mediated gene transfer in the treatment of muscular dystrophies.
2001 Jan 20
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:24:34 UTC 2023
Edited
by admin
on Sat Dec 16 17:24:34 UTC 2023
Record UNII
9WV7GXM6T5
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CREATINE ALPHA-KETOGLUTARATE
Common Name English
PENTANEDIOIC ACID, 2-OXO-, COMPD. WITH N-(AMINOIMINOMETHYL)-N-METHYLGLYCINE (1:1)
Common Name English
GLYCINE, N-(AMINOIMINOMETHYL)-N-METHYL-, 2-OXOPENTANEDIOATE (1:1)
Common Name English
CREATINE AKG
Common Name English
Code System Code Type Description
CAS
315669-78-4
Created by admin on Sat Dec 16 17:24:34 UTC 2023 , Edited by admin on Sat Dec 16 17:24:34 UTC 2023
PRIMARY
PUBCHEM
9925587
Created by admin on Sat Dec 16 17:24:34 UTC 2023 , Edited by admin on Sat Dec 16 17:24:34 UTC 2023
PRIMARY
FDA UNII
9WV7GXM6T5
Created by admin on Sat Dec 16 17:24:34 UTC 2023 , Edited by admin on Sat Dec 16 17:24:34 UTC 2023
PRIMARY
Related Record Type Details
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