DIMEFLINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H21NO3
Molecular Weight	323.3856
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C2C(=O)C(C)=C(OC2=C1CN(C)C)C3=CC=CC=C3

InChI

InChIKey=ZXFQRFXLFWWKLX-UHFFFAOYSA-N

InChI=1S/C20H21NO3/c1-13-18(22)15-10-11-17(23-4)16(12-21(2)3)20(15)24-19(13)14-8-6-5-7-9-14/h5-11H,12H2,1-4H3

HIDE SMILES / InChI

Molecular Formula	C20H21NO3
Molecular Weight	323.3856
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugs.com/international/dimefline.html | https://www.whocc.no/atc_ddd_index/?code=R07AB08

DIMEFLINE is a pneumokinetic and respiratory stimulant. It has been used for the treatment of respiratory insufficiency. The mechanism of action is unknown.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Asthma 244 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14228359	Primary	Not Provided 511	DIMEFLINE Approved Use DIMEFLINE is a pneumokinetic and respiratory stimulant
Respiratory insufficiency 6 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14058024 https://www.ncbi.nlm.nih.gov/pubmed/14497284 https://www.ncbi.nlm.nih.gov/pubmed/13902955	Primary	Not Provided 511	DIMEFLINE Approved Use DIMEFLINE is a pneumokinetic and respiratory stimulant
Pulmonary emphysema 6 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13865840 https://www.ncbi.nlm.nih.gov/pubmed/14091909	Primary	Not Provided 511	DIMEFLINE Approved Use DIMEFLINE is a pneumokinetic and respiratory stimulant

PubMed

Title	Date	PubMed
Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds.	1994-08-03	7520698
A NEW PNEUMOKINETIC DRUG (DIMEFLINE) IN THE TREATMENT OF BRONCHIAL ASTHMA.	1964-11	14228359
DIMEFLINE, A NEW RESPIRATORY ANALEPTIC. PNEUMOTACHOGRAPHIC STUDIES ON PATIENTS WITH RESPIRATORY INSUFFICIENCY.	1963	14058024

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:18:55 GMT 2025` Edited by `admin` on `Mon Mar 31 18:18:55 GMT 2025`
Record UNII	9WII5M0DU3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NSC-169869

Preferred Name

English

DIMEFLINE

Official Name

English

4H-1-BENZOPYRAN-4-ONE, 8-((DIMETHYLAMINO)METHYL)-7-METHOXY-3-METHYL-2-PHENYL-

Systematic Name

English

Dimefline [WHO-DD]

Common Name

English

DIMEFLINE [HSDB]

Common Name

English

dimefline [INN]

Common Name

English

8-((DIMETHYLAMINO)METHYL)-7-METHOXY-3-METHYLFLAVONE

Systematic Name

English

DIMEFLINE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47795