FENPYROXIMATE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H27N3O4
Molecular Weight	421.4889
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1N=C(C)C(\C=N\OCC2=CC=C(C=C2)C(=O)OC(C)(C)C)=C1OC3=CC=CC=C3

InChI

InChIKey=YYJNOYZRYGDPNH-MFKUBSTISA-N

InChI=1S/C24H27N3O4/c1-17-21(22(27(5)26-17)30-20-9-7-6-8-10-20)15-25-29-16-18-11-13-19(14-12-18)23(28)31-24(2,3)4/h6-15H,16H2,1-5H3/b25-15+

HIDE SMILES / InChI

Molecular Formula	C24H27N3O4
Molecular Weight	421.4889
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27495808 | https://www.ncbi.nlm.nih.gov/pubmed/22353032

FENPYROXIMATE is a pyrazole acaricide widely used in the prevention of acarids (mites) in fruit plant gardens. It is a potent inhibitor of the mitochondrial proton-translocating NADH-quinone oxidoreductase (complex I).

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
Acute neurotoxicity following Fenpyroximate poisoning	2018-12-31	30669214
123I-FP-CIT SPECT and MRI Findings in a Patient With Parkinsonism After Fenpyroximate Intoxication.	2018-06	29629914
Population-level effects of abamectin, azadirachtin and fenpyroximate on the predatory mite Neoseiulus baraki.	2016-10	27495808
Fenpyroximate binds to the interface between PSST and 49 kDa subunits in mitochondrial NADH-ubiquinone oxidoreductase.	2012-03-06	22353032
Environmental impact on vascular development predicted by high-throughput screening.	2011-11	21788198
Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets.	2011-03-28	21251949
Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.	2010-03-15	20143881
Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress.	2008-05-07	18463239
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.	2005-12-30	16239214

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:07:38 GMT 2025` Edited by `admin` on `Mon Mar 31 19:07:38 GMT 2025`
Record UNII	9W557V4RYA
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FENPYROXIMATE

Common Name

English

FUJIMITE

Preferred Name

English

NNI-850

Code

English

HOE-555-02A

Code

English

TERT-BUTYL (E)-.ALPHA.-(1,3-DIMETHYL-5-PHENOXYPYRAZOL-4-YLMETHYLENEAMINOOXY)-P-TOLUATE

Common Name

English

4-((((E)-((1,3-DIMETHYL-5-PHENOXY-1H-PYRAZOL-4-YL)METHYLENE)AMINO)OXY)METHYL)BENZOIC ACID 1,1-DIMETHYLETHYL ESTER

Systematic Name

English

FENPYROXIMATE [ISO]

Common Name

English

SEQUEL

Brand Name

English

FENPYROXIMATE [MI]

Common Name

English

FENPYROXIMATE (Z,E)

Common Name

English

FENPRYROXIMATE

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

129131