Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C27H36N2O4.ClH |
| Molecular Weight | 489.047 |
| Optical Activity | ( - ) |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.COC(=O)C1=CC=CC(CCN(C)CCC[C@](C#N)(C(C)C)C2=CC(OC)=C(OC)C=C2)=C1
InChI
InChIKey=JHOAIMAMBNLIMD-YCBFMBTMSA-N
InChI=1S/C27H36N2O4.ClH/c1-20(2)27(19-28,23-11-12-24(31-4)25(18-23)32-5)14-8-15-29(3)16-13-21-9-7-10-22(17-21)26(30)33-6;/h7,9-12,17-18,20H,8,13-16H2,1-6H3;1H/t27-;/m0./s1
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C27H36N2O4 |
| Molecular Weight | 452.5857 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( - ) |
Etripamil is a non-dihydropyridine, L-type calcium channel blocker. Currently, etripamil is in Phase 3 development for the treatment of paroxysmal supraventricular tachycardia. Milestone Pharmaceuticals is also developing etripamil to provide rapid heartbeat control for patients living with atrial fibrillation and acute symptom relief for patients with angina.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| High-density mapping of the slow pathway in a patient with atrioventricular nodal reentry given intranasal Etripamil during the NODE-1 study. | 2017 Oct |
|
| Etripamil Nasal Spray for Rapid Conversion of Supraventricular Tachycardia to Sinus Rhythm. | 2018 Jul 31 |
|
| Etripamil: Self-management of supraventricular tachycardia is not far away? | 2019 Mar |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 20:13:32 GMT 2023
by
admin
on
Sat Dec 16 20:13:32 GMT 2023
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| Record UNII |
9TA9AC3H8Z
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| Record Status |
Validated (UNII)
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| Record Version |
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9TA9AC3H8Z
Created by
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2560549-35-9
Created by
admin on Sat Dec 16 20:13:32 GMT 2023 , Edited by admin on Sat Dec 16 20:13:32 GMT 2023
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