Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2H6N2O.ClH |
| Molecular Weight | 110.543 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.NCC(N)=O
InChI
InChIKey=WKNMKGVLOWGGOU-UHFFFAOYSA-N
InChI=1S/C2H6N2O.ClH/c3-1-2(4)5;/h1,3H2,(H2,4,5);1H
| Molecular Formula | C2H6N2O |
| Molecular Weight | 74.0818 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Practical asymmetric synthesis of vicinal diamines through the catalytic highly enantioselective alkylation of glycine amide derivatives. | 2003 |
|
| Deaza analogs of folic acid as antitumor agents. | 2003 |
|
| Tomoregulin ectodomain shedding by proinflammatory cytokines. | 2003 Aug 15 |
|
| Using a residue clash map to functionally characterize protein recombination hybrids. | 2003 Dec |
|
| Membrane topology of guinea pig cytochrome P450 17 alpha revealed by a combination of chemical modifications and mass spectrometry. | 2003 Dec 16 |
|
| A defect in the p53 response pathway induced by de novo purine synthesis inhibition. | 2003 Dec 5 |
|
| Current data with pemetrexed (Alimta) in non-small-cell lung cancer. | 2003 Jan |
|
| The role of Pemetrexed (Alimta , LY231514) in lung cancer therapy. | 2003 Jul |
|
| Metal-catalyzed hydroxylaminolysis of unactivated amide and peptide bonds. | 2003 Mar 7 |
|
| LY309887, antifolate via the folate receptor suppresses murine type II collagen-induced arthritis. | 2003 Nov-Dec |
|
| On the structural and functional modularity of glycinamide ribonucleotide formyltransferases. | 2003 Oct |
|
| Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway. | 2003 Oct 1 |
|
| 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase. | 2003 Oct 1 |
|
| Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase. | 2003 Oct 1 |
|
| FDA drug approval summaries: pemetrexed (Alimta). | 2004 |
|
| CHF 3381. | 2004 |
|
| Pharmacology and mechanism of action of pemetrexed. | 2004 Apr |
|
| The crystal structure of the hydrolase domain of 10-formyltetrahydrofolate dehydrogenase: mechanism of hydrolysis and its interplay with the dehydrogenase domain. | 2004 Apr 2 |
|
| A quantum chemical study of the water-assisted mechanism in one-carbon unit transfer reaction catalyzed by glycinamide ribonucleotide transformylase. | 2004 Aug 1 |
|
| A second-generation system for unbiased reading frame selection. | 2004 Jul |
|
| BMS-201620: a selective beta 3 agonist. | 2004 Jul 5 |
|
| Pemetrexed (ALIMTA), a novel multitargeted antineoplastic agent. | 2004 Jun 15 |
|
| Basal jawed vertebrate phylogeny inferred from multiple nuclear DNA-coded genes. | 2004 Mar 11 |
|
| Analysis of antigen-specific T-cell responses with synthetic peptides--what kind of peptide for which purpose? | 2004 May |
|
| Translational research with pemetrexed in breast cancer. | 2004 Nov |
|
| Overview of phase I/II pemetrexed studies. | 2004 Nov |
|
| Biochemical pharmacology of pemetrexed. | 2004 Nov |
|
| Phase II clinical trial of capecitabine and gemcitabine chemotherapy in patients with metastatic renal carcinoma. | 2004 Nov 15 |
|
| Double proton transfer behavior and one-electron oxidation effect in double H-bonded glycinamide-formic acid complex. | 2004 Nov 22 |
|
| Highly stereoselective Michael addition reactions of CamTHP*-desymmetrized glycinamide for the synthesis of functionally dense amino acid derivatives. | 2004 Nov 25 |
|
| CamTHP*OH: a camphor-derived delta-lactol auxiliary for the effective desymmetrization of attached glycinamide residues. Asymmetric synthesis of alpha-amino carbonyl compounds. | 2004 Nov 25 |
|
| Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivo. | 2004 Oct 1 |
|
| Construction, characterization, and use of small-insert gene banks of DNA isolated from soil and enrichment cultures for the recovery of novel amidases. | 2004 Sep |
|
| Tumor necrosis factor alpha stimulates MUC1 synthesis and ectodomain release in a human uterine epithelial cell line. | 2004 Sep |
|
| Three emerging new drugs for NSCLC: pemetrexed, bortezomib, and cetuximab. | 2005 Apr |
|
| Sister group relationship of turtles to the bird-crocodilian clade revealed by nuclear DNA-coded proteins. | 2005 Apr |
|
| Crystal structure and mechanism of the Escherichia coli ArnA (PmrI) transformylase domain. An enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance. | 2005 Apr 12 |
|
| Highly enantioselective phase-transfer-catalyzed alkylation of protected alpha-amino acid amides toward practical asymmetric synthesis of vicinal diamines, alpha-amino ketones, and alpha-amino alcohols. | 2005 Apr 13 |
|
| Arylamide dendrimers with flexible linkers via haloacyl halide method. | 2005 Apr 28 |
|
| Double proton transfer and one-electron oxidation behavior in double H-bonded glycinamide-glycine complex in the gas phase. | 2005 Apr 30 |
|
| Chiral ion-exchange capillary electrochromatography of arylglycine amides with dextran sulfate as a pseudostationary phase. | 2005 Feb |
|
| Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis. | 2005 Feb 1 |
|
| Glycine-amide is an active metabolite of the antiretroviral tripeptide glycyl-prolyl-glycine-amide. | 2005 Jan |
|
| Specific inhibition and stabilization of aspergilloglutamic peptidase by the propeptide. Identification of critical sequences and residues in the propeptide. | 2005 Jan 14 |
|
| Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells. | 2005 Jul |
|
| Kinetic and mechanistic investigation of the selective acidolysis of the C-terminal amide bond of N-acyl-N,alpha,alpha-trialkyl glycine amides. | 2005 Jul |
|
| Molecular characterization and chromosomal assignment of the bovine glycinamide ribonucleotide formyltransferase (GART) gene on cattle chromosome 1q12.1-q12.2. | 2005 Mar 28 |
|
| Application of intramolecular 1,3-dipolar cyclic addition of azide and olefin; construction of (pyrrolidine-2-ylidene)glycinate and glycinamides. | 2005 May |
|
| Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway. | 2005 May 16 |
|
| Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway. | 2005 May 16 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 19:12:33 GMT 2023
by
admin
on
Sat Dec 16 19:12:33 GMT 2023
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| Record UNII |
9SPG4KUG6A
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| Record Status |
Validated (UNII)
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| Record Version |
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2723639
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9SPG4KUG6A
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DTXSID60937242
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1668-10-6
Created by
admin on Sat Dec 16 19:12:34 GMT 2023 , Edited by admin on Sat Dec 16 19:12:34 GMT 2023
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|---|---|---|---|---|
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