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Details

Stereochemistry ACHIRAL
Molecular Formula C2H6N2O.ClH
Molecular Weight 110.543
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Glycinamide hydrochloride

SMILES

Cl.NCC(N)=O

InChI

InChIKey=WKNMKGVLOWGGOU-UHFFFAOYSA-N
InChI=1S/C2H6N2O.ClH/c3-1-2(4)5;/h1,3H2,(H2,4,5);1H

HIDE SMILES / InChI

Molecular Formula C2H6N2O
Molecular Weight 74.0818
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors.
2001
Synthetic Cu(II) and Ni(II) peptidases.
2001
Increased shedding of angiotensin-converting enzyme by a mutation identified in the stalk region.
2001 Feb 23
Synthesis and biological activity of 7-oxo substituted analogues of 5-deaza-5,6,7,8-tetrahydrofolic acid (5-DATHF) and 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF).
2001 Jul 5
Involvement of a transformylase enzyme in siderophore synthesis in Pseudomonas aeruginosa.
2001 Jun
A permissive role for tumor necrosis factor in vascular endothelial growth factor-induced vascular permeability.
2001 Mar 1
Proton transfer dynamics of GART: the pH-dependent catalytic mechanism examined by electrostatic calculations.
2001 Nov
Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase.
2001 Nov 13
Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck.
2001 Sep 1
Pemetrexed in the treatment of selected solid tumors.
2002 Apr
Pemetrexed: a promising new treatment for breast cancer.
2002 Apr
The pemetrexed/gemcitabine combination in pancreatic cancer.
2002 Aug 15
A universal, vector-based system for nucleic acid reading-frame selection.
2002 Dec
Pemetrexed: an active new agent for breast cancer.
2002 Dec
Pemetrexed safety and dosing strategy.
2002 Dec
Molecular, biochemical, and cellular pharmacology of pemetrexed.
2002 Dec
Effect of short-term N(2) deficiency on expression of the ureide pathway in cowpea root nodules.
2002 Jul
Synthesis of a new antischistosomally active and toxicologically tolerant C-12 monothione surrogate of the universal antihelmintic praziquantel.
2002 Jul-Aug
Pemetrexed: translational research in breast cancer.
2002 Jun
Alimta (pemetrexed disodium): a multitargeted antifolate for the treatment of mesothelioma.
2002 Nov
Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163.
2002 Oct
Deaza analogs of folic acid as antitumor agents.
2003
Pemetrexed (Alimta): a promising new agent for the treatment of breast cancer.
2003 Apr
Thymidine and hypoxanthine protection patterns of the folic acid-enhanced synergies for combinations of trimetrexate plus a polyglutamylatable inhibitor of purine or thymidylate synthesis against human ileocecal HCT-8 cells.
2003 Aug
Tomoregulin ectodomain shedding by proinflammatory cytokines.
2003 Aug 15
A defect in the p53 response pathway induced by de novo purine synthesis inhibition.
2003 Dec 5
Antineoplastic agents. 487. Synthesis and biological evaluation of the antineoplastic agent 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene and derived amino acid amides.
2003 Feb 13
Current data with pemetrexed (Alimta) in non-small-cell lung cancer.
2003 Jan
The role of Pemetrexed (Alimta , LY231514) in lung cancer therapy.
2003 Jul
Novel antifolate drugs.
2003 Mar
Pemetrexed and its emerging role in the treatment of thoracic malignancies.
2003 May
Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.
2003 Oct 1
CHF 3381.
2004
The crystal structure of the hydrolase domain of 10-formyltetrahydrofolate dehydrogenase: mechanism of hydrolysis and its interplay with the dehydrogenase domain.
2004 Apr 2
A quantum chemical study of the water-assisted mechanism in one-carbon unit transfer reaction catalyzed by glycinamide ribonucleotide transformylase.
2004 Aug 1
Translational research with pemetrexed in breast cancer.
2004 Nov
Overview of phase I/II pemetrexed studies.
2004 Nov
Double proton transfer behavior and one-electron oxidation effect in double H-bonded glycinamide-formic acid complex.
2004 Nov 22
Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivo.
2004 Oct 1
Construction, characterization, and use of small-insert gene banks of DNA isolated from soil and enrichment cultures for the recovery of novel amidases.
2004 Sep
Sister group relationship of turtles to the bird-crocodilian clade revealed by nuclear DNA-coded proteins.
2005 Apr
Arylamide dendrimers with flexible linkers via haloacyl halide method.
2005 Apr 28
Chiral ion-exchange capillary electrochromatography of arylglycine amides with dextran sulfate as a pseudostationary phase.
2005 Feb
Glycine-amide is an active metabolite of the antiretroviral tripeptide glycyl-prolyl-glycine-amide.
2005 Jan
Molecular characterization and chromosomal assignment of the bovine glycinamide ribonucleotide formyltransferase (GART) gene on cattle chromosome 1q12.1-q12.2.
2005 Mar 28
Application of intramolecular 1,3-dipolar cyclic addition of azide and olefin; construction of (pyrrolidine-2-ylidene)glycinate and glycinamides.
2005 May
Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway.
2005 May 16
Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.
2005 May 16
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 16 19:12:33 GMT 2023
Edited
by admin
on Sat Dec 16 19:12:33 GMT 2023
Record UNII
9SPG4KUG6A
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Glycinamide hydrochloride
Common Name English
2-Aminoacetamide hydrochloride
Systematic Name English
Acetamide, 2-amino-, hydrochloride (1:1)
Systematic Name English
Glycine amide hydrochloride
Common Name English
Code System Code Type Description
PUBCHEM
2723639
Created by admin on Sat Dec 16 19:12:34 GMT 2023 , Edited by admin on Sat Dec 16 19:12:34 GMT 2023
PRIMARY
FDA UNII
9SPG4KUG6A
Created by admin on Sat Dec 16 19:12:34 GMT 2023 , Edited by admin on Sat Dec 16 19:12:34 GMT 2023
PRIMARY
EPA CompTox
DTXSID60937242
Created by admin on Sat Dec 16 19:12:34 GMT 2023 , Edited by admin on Sat Dec 16 19:12:34 GMT 2023
PRIMARY
CAS
1668-10-6
Created by admin on Sat Dec 16 19:12:34 GMT 2023 , Edited by admin on Sat Dec 16 19:12:34 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE