SKF-86002

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H12FN3S
Molecular Weight	297.35
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC=C(C=C1)C2=C(N3CCSC3=N2)C4=CC=NC=C4

InChI

InChIKey=YOELZIQOLWZLQC-UHFFFAOYSA-N

InChI=1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2

HIDE SMILES / InChI

Molecular Formula	C16H12FN3S
Molecular Weight	297.35
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Potency
Arachidonate 5-lipoxygenase 49 Target ID: P09917 Gene ID: 240.0 Gene Symbol: ALOX5 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8831759	Inhibitor 8297	10.0 µM [IC50]
Prostaglandin G/H synthase 1 30 Target ID: P23219\|\|\|Q5T7T7 Gene ID: 5742.0 Gene Symbol: PTGS1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8831759	Inhibitor 8297	5.4 µM [IC50]
MAP kinase p38 5 Target ID: CHEMBL2094115 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9525949	Inhibitor 8297

PubMed

Title	Date	PubMed
1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.	1996 Sep 27	8831759
p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils.	1998 Apr 3	9525949

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:34:31 UTC 2023` Edited by `admin` on `Sat Dec 16 09:34:31 UTC 2023`
Record UNII	9R6QDF1UO7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SKF-86002

Common Name

English

SK&F-86002

Code

English

IMIDAZO(2,1-B)THIAZOLE, 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)-

Systematic Name

English

6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO(2,1-B)THIAZOLE

Systematic Name

English

KSF-86002

Code

English

Code System Code Type Description

PUBCHEM

5228

Created by admin on Sat Dec 16 09:34:31 UTC 2023 , Edited by admin on Sat Dec 16 09:34:31 UTC 2023

PRIMARY

FDA UNII

9R6QDF1UO7

Created by admin on Sat Dec 16 09:34:31 UTC 2023 , Edited by admin on Sat Dec 16 09:34:31 UTC 2023

PRIMARY

EPA CompTox

DTXSID70223168

Created by admin on Sat Dec 16 09:34:31 UTC 2023 , Edited by admin on Sat Dec 16 09:34:31 UTC 2023

PRIMARY

CAS

72873-74-6

Created by admin on Sat Dec 16 09:34:31 UTC 2023 , Edited by admin on Sat Dec 16 09:34:31 UTC 2023

PRIMARY

Related Record Type Details


					URP3G75J4S

MITOGEN-ACTIVATED PROTEIN KINASE 14

TARGET -> INHIBITOR