LOCICORTOLONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H28Cl2O3
Molecular Weight	411.362
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@H](Cl)[C@@]3(Cl)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

InChIKey=FKRMBGXNTOTQDI-IIEHVVJPSA-N

InChI=1S/C22H28Cl2O3/c1-12-8-16-15-5-4-13-9-14(26)6-7-21(13,3)22(15,24)18(23)10-20(16,2)19(12)17(27)11-25/h6-7,9,12,15-16,18-19,25H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C22H28Cl2O3
Molecular Weight	411.362
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.chemdrug.com/article/8/3284/16419499.html | https://www.ncbi.nlm.nih.gov/pubmed/7062053 | https://www.ncbi.nlm.nih.gov/pubmed/6113176

Locicortolone is an anti-inflammatory and antiallergic synthetic glucocorticoid. It has high glucocorticoid cytoplasmic receptor binding affinity in vitro (more than four times higher than dexamethasone) but comparable to dexamethasone relative TAT (tyrosine aminotransferase induction) activity. It has six times lower binding affinity to mineralocorticoid receptor in comparison to dexamethasone.

Originator

Approval Year

PubMed

Title	Date	PubMed
Relations between steroid-cell contact, steroid-binding and induction of tyrosine aminotransferase.	1981 May	6113176
Ornithine decarboxylase induction by glucocorticoids in brain and liver of adrenalectomized rats.	1982 May	7062053
Binding of steroids to the progestin and glucocorticoid receptors analyzed by correspondence analysis.	1988 Jun	2897467

Sample Use Guides

In Vivo Use Guide

Single dose - 1 mg per rat

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Fri Dec 15 20:11:15 UTC 2023` Edited by `admin` on `Fri Dec 15 20:11:15 UTC 2023`
Record UNII	9R09I46GBS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LOCICORTOLONE

Common Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 9,11-DICHLORO-21-HYDROXY-16-METHYL-, (11.BETA.,16.ALPHA.)-

Systematic Name

English

RU-24476

Common Name

English

Code System Code Type Description

PUBCHEM

12905327