Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C8H8O |
| Molecular Weight | 120.1485 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C1OC1C2=CC=CC=C2
InChI
InChIKey=AWMVMTVKBNGEAK-UHFFFAOYSA-N
InChI=1S/C8H8O/c1-2-4-7(5-3-1)8-6-9-8/h1-5,8H,6H2
| Molecular Formula | C8H8O |
| Molecular Weight | 120.1485 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Styrene-7,8-oxide. | 2002 |
|
| Chemicals studied and evaluated in long-term carcinogenesis bioassays by both the Ramazzini Foundation and the National Toxicology Program: in tribute to Cesare Maltoni and David Rall. | 2002 Dec |
|
| Carcinogenicity and mechanistic insights on the behavior of epoxides and epoxide-forming chemicals. | 2002 Dec |
|
| The repair of DNA damage induced in human peripheral lymphocytes with styrene oxide. | 2003 |
|
| Genetic polymorphism of drug-metabolizing enzymes and styrene-induced DNA damage. | 2003 |
|
| Individual sensitivity to DNA damage induced by styrene in vitro: influence of cytochrome p450, epoxide hydrolase and glutathione S-transferase genotypes. | 2003 Apr 15 |
|
| Effect of epoxide hydrolase and glutathione S-tranferase genotypes on the induction of micronuclei and DNA damage by styrene-7,8-oxide in vitro. | 2003 Apr 20 |
|
| Simultaneous direct electrochemiluminescence and catalytic voltammetry detection of DNA in ultrathin films. | 2003 Apr 30 |
|
| Enzymatic transformations. Immobilized A. niger epoxide hydrolase as a novel biocatalytic tool for repeated-batch hydrolytic kinetic resolution of epoxides. | 2003 Aug 7 |
|
| Association properties of ethylene oxide/styrene oxide diblock copolymer E17S8 in aqueous solution. | 2003 Jul 1 |
|
| [Neurotoxic effect of 7,8-oxide styrene on striatal neuron culture]. | 2003 Jul-Sep |
|
| [Definition of neurotoxic risk based on the benchmark dose in vitro: illustration with experimental models based on the use of known neurotoxic substances]. | 2003 Jul-Sep |
|
| Models of neurotoxicity: extrapolation of benchmark doses in vitro. | 2003 Jun |
|
| Assessment of biotransformation of the arene moiety of styrene in volunteers and occupationally exposed workers. | 2003 Jun 15 |
|
| Styrene-7,8-oxide activates a complex apoptotic response in neuronal PC12 cell line. | 2003 Mar |
|
| Epoxidation of styrene by human cyt P450 1A2 by thin film electrolysis and peroxide activation compared to solution reactions. | 2003 May 1 |
|
| Asymmetric environments in encapsulation complexes. | 2003 May 21 |
|
| Construction of a bacterial biosensor for styrene. | 2003 May 8 |
|
| In vitro metabolism of styrene to styrene oxide in liver and lung of Cyp2E1 knockout mice. | 2003 May 9 |
|
| Quantitative analysis of modified proteins by LC-MS/MS of peptides labeled with phenyl isocyanate. | 2003 May-Jun |
|
| A facile solid-phase synthesis of substituted 2(5H)-furanones from polymer-supported alpha-selenocarboxylic acids. | 2003 May-Jun |
|
| Evaluation of bioanalytical assays for toxicity assessment and mode of toxic action classification of reactive chemicals. | 2003 Nov 1 |
|
| Epoxide-opening and group-transfer reactions mediated by monomeric zirconium imido complexes. | 2003 Nov 26 |
|
| Kinetics and mechanism of rhenium-catalyzed O atom transfer from epoxides. | 2003 Sep 10 |
|
| Influence of genetic polymorphisms on biomarkers of exposure and genotoxic effects in styrene-exposed workers. | 2004 |
|
| Donor ligand effect on the nature of the oxygenating species in Mn(III)(salen)-catalyzed epoxidation of olefins: experimental evidence for multiple active oxidants. | 2004 Apr 19 |
|
| A new role for glutathione: protection of vitamin B12 from depletion by xenobiotics. | 2004 Dec |
|
| Two-sample scale tests for comparison of metabolic rates for styrene in previously exposed and unexposed groups. | 2004 Feb 28 |
|
| Enantioselective hydrolysis of various substituted styrene oxides with Aspergillus Niger CGMCC 0496. | 2004 Feb 7 |
|
| A novel approach based on solid phase microextraction gas chromatography and mass spectrometry to the determination of highly reactive organic compounds in cells cultures: styrene oxide. | 2004 Jan |
|
| A recombinant model for assessing the role of GSTM1 in styrene-7,8-oxide toxicity and mutagenicity. | 2004 Jan 15 |
|
| Direct electrochemiluminescence detection of oxidized DNA in ultrathin films containing [Os(bpy)2(PVP)10]2+. | 2004 Jul 21 |
|
| Influence of selected inhibitors on the metabolism of the styrene metabolite 4-vinylphenol in wild-type and CYP2E1 knockout mice. | 2004 Jun 25 |
|
| Mechanistic approaches for evaluating the toxicity of reactive organochlorines and epoxides in green algae. | 2004 Mar |
|
| Colorimetric high-throughput assay for alkene epoxidation catalyzed by cytochrome P450 BM-3 variant 139-3. | 2004 Mar |
|
| Unique reactions of glycosyl iodides with oxa- and thiocycloalkane acceptors. | 2004 Mar 18 |
|
| Comparison of the susceptibility of wild-type and CYP2E1 knockout mice to the hepatotoxic and pneumotoxic effects of styrene and styrene oxide. | 2004 May 2 |
|
| An efficient synthesis of 2-amino alcohols by silica gel catalysed opening of epoxide rings by amines. | 2004 May 7 |
|
| Styrene 7,8-oxide induces mitochondrial damage and oxidative stress in neurons. | 2004 Sep 1 |
|
| Quantitative measurement of DNA adducts using neutral hydrolysis and LC-MS. Validation of genotoxicity sensors. | 2005 Apr 1 |
|
| Solubilisation in aqueous micellar solutions of block copoly(oxyalkylene)s. | 2005 Apr 11 |
|
| Multistate reactivity in styrene epoxidation by compound I of cytochrome p450: mechanisms of products and side products formation. | 2005 Apr 22 |
|
| Analysis of oxidative stress in SK-N-MC neurons exposed to styrene-7,8-oxide. | 2005 Feb |
|
| Ring-oxidized metabolites of styrene contribute to styrene-induced Clara-cell toxicity in mice. | 2005 Feb 13 |
|
| Purification and characterization of a yeast carbonyl reductase for synthesis of optically active (R)-styrene oxide derivatives. | 2005 Jan |
|
| Review of the in vivo genotoxicity tests performed with styrene. | 2005 Jan |
|
| Styrene oxide DNA adducts: quantitative determination using 31P monitoring. | 2005 Jan |
|
| Comparison of the depletion of glutathione in mouse liver and lung following administration of styrene and its metabolites styrene oxide and 4-vinylphenol. | 2005 Jan 31 |
|
| Molecular modelling of human microsomal epoxide hydrolase (EH) by homology with a fungal (Aspergillus niger) EH crystal structure of 1.8 A resolution: structure-activity relationships in epoxides inhibiting EH activity. | 2005 Jun |
|
| Size control of styrene oxide-ethylene oxide diblock copolymer aggregates with classical surfactants: DLS, TEM, and ITC study. | 2005 May-Jun |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:25:10 UTC 2023
by
admin
on
Sat Dec 16 08:25:10 UTC 2023
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| Record UNII |
9QH06NGT6O
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| Record Status |
Validated (UNII)
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| Record Version |
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NCI_THESAURUS |
C45408
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9QH06NGT6O
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96-09-3
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2646
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637
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17907
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DTXSID2021286
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Styrene-7,8-oxide
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7276
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7582
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C44447
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202-476-7
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