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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 15:51:11 GMT 2025
Edited
by admin
on Wed Apr 02 15:51:11 GMT 2025
Protein Type MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type IGG1
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
9Q5A23K7V5
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Immunoglobulin G1 [233-alanine,234-alanine,327-arginine,de-446-lysine], anti-(human transferrin receptor 1) (human-Mus musculus monoclonal AV01 ?1-chain), disulfide with human-Mus musculus monoclonal AV01 ?-chain, dimer, reduced, 214(or 219)-thioether wi
Preferred Name English
Delpacibart Braxlosiran
INN  
Official Name English
delpacibart braxlosiran [INN]
Common Name English
immunoglobulin G1-kappa, anti-[Homo sapiens TFRC (transferrin receptor, TfR1, TFR1, CD71)], humanized monoclonal antibody, conjugated on an average of one cysteinyl residue via a 4-(maleimidomethyl)cyclohexanecarboxamide linker with a double-stranded sma
Common Name English
H-gamma1 heavy chain humanized (1-445) [VH (Homo sapiens IGHV1-2*06 (87.8%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-116) -Homo sapiens IGHG1*03,G1m3, nG1m1 CH1 R120, CH3 E12, M14, G1v14 CH2 A1.3, A1.2, G1v48 CH2 R113 (CH1 R120
Common Name English
Code System Code Type Description
INN
13251
Created by admin on Wed Apr 02 15:51:11 GMT 2025 , Edited by admin on Wed Apr 02 15:51:11 GMT 2025
PRIMARY
SMS_ID
300000046774
Created by admin on Wed Apr 02 15:51:11 GMT 2025 , Edited by admin on Wed Apr 02 15:51:11 GMT 2025
PRIMARY
CAS
2929261-85-6
Created by admin on Wed Apr 02 15:51:11 GMT 2025 , Edited by admin on Wed Apr 02 15:51:11 GMT 2025
PRIMARY
FDA UNII
9Q5A23K7V5
Created by admin on Wed Apr 02 15:51:11 GMT 2025 , Edited by admin on Wed Apr 02 15:51:11 GMT 2025
PRIMARY
NCI_THESAURUS
C211752
Created by admin on Wed Apr 02 15:51:11 GMT 2025 , Edited by admin on Wed Apr 02 15:51:11 GMT 2025
PRIMARY
From To
1_22 1_96
2_22 2_96
2_143 2_199
2_219 4_214
2_260 2_320
1_143 1_199
2_366 2_424
3_23 3_88
3_134 3_194
4_23 4_88
4_134 4_194
1_219 3_214
1_225 2_225
1_228 2_228
1_260 1_320
1_366 1_424
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_296
N 2_296
Related Record Type Details
Delpacibart
PARENT -> CONJUGATE
Related Record Type Details
Delpacibart Braxlosiran
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_1] [2_1] N-TERMINUS Q PIDOLIC ACID SZB83O1W42
AMINO_ACID_SUBSTITUTION [1_219] [1_225] [1_228] [2_219] [2_225] [2_228] [3_214] [4_214] SITE_SPECIFIC C Amount: UNSPECIFIED SUBSTANCE
77bb037a
(not in database)
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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