ALUMINUM FLUFENAMATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	3C14H9F3NO2.Al
Molecular Weight	867.6474
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Al+3].[O-]C(=O)C1=CC=CC=C1NC2=CC(=CC=C2)C(F)(F)F.[O-]C(=O)C3=CC=CC=C3NC4=CC(=CC=C4)C(F)(F)F.[O-]C(=O)C5=CC=CC=C5NC6=CC(=CC=C6)C(F)(F)F

InChI

InChIKey=OSQHGAXCVAYZPZ-UHFFFAOYSA-K

InChI=1S/3C14H10F3NO2.Al/c3*15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20;/h3*1-8,18H,(H,19,20);/q;;;+3/p-3

HIDE SMILES / InChI

Molecular Formula	Al
Molecular Weight	26.9815
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C14H9F3NO2
Molecular Weight	280.222
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7097486 | https://www.ncbi.nlm.nih.gov/pubmed/4590059 | https://www.mimaki-family-japan.com/item/detail?item_prefix=TF&item_code=002483&item_branch=001

Aluminum flufenamate is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically. Antiphlogistic pain reliever Opyrin (Aluminum flufenamate) was launched in Japan by Taisho Pharmaceutical in 1967.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cyclooxygenase-1 127 Target ID: CHEMBL221 Sources: http://www.genome.jp/dbget-bin/www_bget?dr:D03254	Inhibitor 8297
Cyclooxygenase-2 196 Target ID: CHEMBL230 Sources: http://www.genome.jp/dbget-bin/www_bget?dr:D03254	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Osteoarthritis 157 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4590059	Primary		Approved 8429	Opyrin Approved Use Rheumatoid arthritis, osteoarthritis Launch Date 1967
Rheumatoid arthritis 316 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4590059	Primary		Approved 8429	Opyrin Approved Use Rheumatoid arthritis, osteoarthritis Launch Date 1967

PubMed

Title	Date	PubMed
Clinical evaluation of naproxen in the treatment of osteoarthritis--double-blind, cross-over trial.	1973	4590059
[Comparative effectiveness of new antirheumatic drugs].	1980	7008232
The bioavailability of flufenamic acid from aluminum flufenamate tablet and flufenamic acid capsule, and the influence of food and aluminum hydroxide gel.	1982 Mar	7097486

Patents

Sample Use Guides

In Vivo Use Guide

Patients with osteoarthritis received aluminium flufenamate in a daily dose of 750 mg for two weeks

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:14:01 GMT 2023` Edited by `admin` on `Fri Dec 15 16:14:01 GMT 2023`
Record UNII	9NZ7H8YAHG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ALUMINUM FLUFENAMATE

Common Name

English

ALUMINIUM FLUFENAMATE

Common Name

English

ALUMINIUM N-(3'-TRIFLUOROMETHYLPHENY)ANTHRANILATE

Common Name

English

ALUMINUM, TRIS(2-((3-(TRIFLUOROMETHYL)PHENYL)AMINO-.KAPPA.N)BENZOATO-.KAPPA.O)-

Common Name

English

BENZOIC ACID, 2-((3-(TRIFLUOROMETHYL)PHENYL)AMINO)-, ALUMINUM SALT(3:1)

Common Name

English

BENZOIC ACID, 2-((3-(TRIFLUOROMETHYL)PHENYL)AMINO)-, ALUMINIUM SALT(3:1)

Common Name

English

Flufenamate aluminium [WHO-DD]

Common Name

English

ALUMINUM N-(3'-TRIFLUOROMETHYLPHENY)ANTHRANILATE

Common Name

English

FLUFENAMATE ALUMINUM [JAN]

Common Name

English

FLUFENAMATE ALUMINIUM

Common Name

English

ALUMINIUM, TRIS(2-((3-(TRIFLUOROMETHYL)PHENYL)AMINO-.KAPPA.N)BENZOATO-.KAPPA.O)-

Common Name

English

ALFENAMIN

Brand Name

English

FLUFENAMIC ACID ALUMINUM SALT [MI]

Common Name

English

OPYRIN

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257