Stereochemistry | ACHIRAL |
Molecular Formula | C10H12O |
Molecular Weight | 148.2017 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=C(CC=C)C=C1
InChI
InChIKey=ZFMSMUAANRJZFM-UHFFFAOYSA-N
InChI=1S/C10H12O/c1-3-4-9-5-7-10(11-2)8-6-9/h3,5-8H,1,4H2,2H3
Molecular Formula | C10H12O |
Molecular Weight | 148.2017 |
Charge | 0 |
Count |
MOL RATIO
1 MOL RATIO (average) |
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Estragole (ES) is a natural constituent of a number of plants (e.g. tarragon, sweet basil and sweet fennel) and their essential oils have been widely used in foodstuffs as flavouring agents. Estragole ES was given GRAS Generally Recognized As Safe status by the Flavor and Extract Manufacturer’s Association FEMA, 1965 and is approved by the Food and Drug Administration for food use 21 CFR code of Federal Regulation 121.1164 . Several studies with oral, i.p. or s.c. administration to CD-1 and B6C3F1 mice have shown the carcinogenicity of ES. In vivo and in vitro experimental assays have shown that EST has sedative, anticonvulsant, antioxidant, antimicrobial, and anesthetic activity.
CNS Activity
Approval Year
PubMed
Patents
Sample Use Guides
In the peritonitis model, Estragole (500 and 750 mg/kg) decreased the infiltration of peritoneal exudate leukocytes.
Route of Administration:
Oral
In vitro chemotaxis assay showed that Estragole (3, 10, 30, and 60 ug/mL) inhibited murine neutrophil migration toward fMLP. Estragole (3, 10, and 30 ug/mL) was able to stimulate the macrophages phagocytosis but only at concentration of 10 ug/mL promoted an increase in nitric oxide (NO) production.