Details
Stereochemistry | ACHIRAL |
Molecular Formula | C15H13NO |
Molecular Weight | 223.2698 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)NC1=CC2=C(C=C1)C3=CC=CC=C3C2
InChI
InChIKey=CZIHNRWJTSTCEX-UHFFFAOYSA-N
InChI=1S/C15H13NO/c1-10(17)16-13-6-7-15-12(9-13)8-11-4-2-3-5-14(11)15/h2-7,9H,8H2,1H3,(H,16,17)
Molecular Formula | C15H13NO |
Molecular Weight | 223.2698 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
PubMed
Title | Date | PubMed |
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Ellagic [correction of ellagica] acid inhibits arylamine N-acetyltransferase activity and DNA adduct formation in human bladder tumor cell lines (T24 and TSGH 8301). | 2001 Dec |
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Leukemia inhibitory factor decreases the arylamine N-acetyltransferase activity in human cumulus granulosa cells. | 2001 Dec |
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SDF-1alpha/CXCR4: a mechanism for hepatic oval cell activation and bone marrow stem cell recruitment to the injured liver of rats. | 2002 |
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Effects of garlic components diallyl sulfide and diallyl disulfide on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adducts in human promyelocytic leukemia cells. | 2002 |
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The drug efflux pump MRP2: regulation of expression in physiopathological situations and by endogenous and exogenous compounds. | 2002 |
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Anti-mutagenic activity of Phyllanthus amarus Schum & Thonn in vitro as well as in vivo. | 2002 |
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Polyetheretherketone--cytotoxicity and mutagenicity in vitro. | 2002 Apr |
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The in vivo apoptotic effect of interferon alfa-2b on rat preneoplastic liver involves Bax protein. | 2002 Apr |
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Anticarcinogenicity of monocyclic phenolic compounds. | 2002 Aug |
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Trapping of DNA nucleotide excision repair factors by nonrepairable carcinogen adducts. | 2002 Aug 1 |
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The Liverbeads as a tool for the comet assay. | 2002 Aug 26 |
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Chemical models for cytochrome P450 as a biomimetic metabolic activation system in mutation assays. | 2002 Aug 26 |
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Deacylation of N-arylformamides and N-arylacetamides by formamidase in rat liver. | 2002 Dec |
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Oxidative DNA damage by a common metabolite of carcinogenic nitrofluorene and N-acetylaminofluorene. | 2002 Dec 1 |
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Distinction of carcinogens from mutagens by induction of liver cell foci in a model for detection of initiation activity. | 2002 Dec 15 |
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Mutagenic events in Escherichia coli and mammalian cells generated in response to acetylaminofluorene-derived DNA adducts positioned in the Nar I restriction enzyme site. | 2002 Dec 3 |
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Lack of DNA binding in the rat nasal mucosa and other tissues of the nasal toxicants roflumilast, a phosphodiesterase 4 inhibitor, and a metabolite, 4-amino-3,5-dichloropyridine, in contrast to the nasal carcinogen 2,6-dimethylaniline. | 2002 Feb |
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In vivo cell lineage analysis in cyproterone acetate-treated rat liver using genetic labeling of hepatocytes. | 2002 Feb |
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Germ cells microsatellite instability. The effect of different mutagens in a mismatch repair mutant of Drosophila (spel1). | 2002 Feb 15 |
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Genetics of mutagenesis in E. coli: various combinations of translesion polymerases (Pol II, IV and V) deal with lesion/sequence context diversity. | 2002 Feb 28 |
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Proliferation and differentiation of ductular progenitor cells and littoral cells during the regeneration of the rat liver to CCl4/2-AAF injury. | 2002 Jan |
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Alteration of liver cell function and proliferation: differentiation between adaptation and toxicity. | 2002 Jan-Feb |
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Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes. | 2002 Jul |
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[Establishment and optimization of rat models for hepatic oval cells proliferation]. | 2002 Jun |
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In vivo cell lineage analysis during chemical hepatocarcinogenesis in rats using retroviral-mediated gene transfer: evidence for dedifferentiation of mature hepatocytes. | 2002 Jun |
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Pleiotrophin/heparin-binding growth-associated molecule as a mitogen of rat hepatocytes and its role in regeneration and development of liver. | 2002 Jun |
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The isomerization of the UvrB-DNA preincision complex couples the UvrB and UvrC activities. | 2002 Jun 28 |
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32P-Postlabeling/polyacrylamide gel electrophoresis analysis: application to the detection of DNA adducts. | 2002 Mar |
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Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling. | 2002 Mar 27 |
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Acute cytotoxicity of the chemical carcinogen 2-acetylaminofluorene in cultured rat liver epithelial cells. | 2002 Mar 28 |
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Alterations of the Fhit gene in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats. | 2002 May |
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The effect of paclitaxel on 2-aminofluorene-DNA adducts formation and arylamine N-acetyltransferase activity and gene expression in human lung tumor cells (A549). | 2002 May |
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Hydrocortisone affects the N-acetylation of 2-aminofluorene and DNA-2-aminofluorene adduct formation in Sprague-Dawley rats. | 2002 May-Jun |
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Protection by beverages, fruits, vegetables, herbs, and flavonoids against genotoxicity of 2-acetylaminofluorene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in metabolically competent V79 cells. | 2002 Nov 26 |
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Influence of different chemicals on MDR-1 P-glycoprotein expression and activity in the HK-2 proximal tubular cell line. | 2002 Sep 1 |
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Mutagenic activation of arylamines by subcellular fractions of Chamaelea gallina clams exposed to environmental pollutants. | 2003 |
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Use of nucleotide excision repair-deficient mice as a model for chemically induced lung cancer. | 2003 |
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Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays. | 2003 Apr 20 |
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Mechanistic insights into replication across from bulky DNA adducts: a mutant polymerase I allows an N-acetyl-2-aminofluorene adduct to be accommodated during DNA synthesis. | 2003 Apr 8 |
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Evidence of a "clear and consistent threshold" for bladder and liver cancer in the large ED01 carcinogenicity study. | 2003 Aug |
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Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats. | 2003 Jan |
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Polychlorinated biphenyls as initiators in liver carcinogenesis: resistant hepatocyte model. | 2003 Jan 1 |
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Pregnane X receptor-dependent and -independent effects of 2-acetylaminofluorene on cytochrome P450 3A23 expression and liver cell proliferation. | 2003 Jan 10 |
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Different effects of the liver mitogens triiodo-thyronine and ciprofibrate on the development of rat hepatocellular carcinoma. | 2003 Jan-Feb |
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Prevalidation of a rat liver foci bioassay (RLFB) based on results from 1600 rats: a study report. | 2003 Jan-Feb |
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Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7. | 2003 Jan-Feb |
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Suppressive effect of herbal compound 861 on chemical hepatocarcinogenesis in rats. | 2003 Mar |
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Thresholds of carcinogenicity in the ED01 study. | 2003 Mar |
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Differentially expressed transcripts in neoplastic hepatic nodules and neonatal rat liver studied by cDNA microarray analysis. | 2003 Mar 20 |
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Uncoupling of leading- and lagging-strand DNA replication during lesion bypass in vivo. | 2003 May 23 |
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:18:21 GMT 2023
by
admin
on
Fri Dec 15 17:18:21 GMT 2023
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Record UNII |
9M98QLJ2DL
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C45176
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m5459
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12279
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4077
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5897
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200-188-6
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2-ACETYLAMINOFLUORENE
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D015073
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DTXSID0039227
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C29791
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C118533
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9M98QLJ2DL
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53-96-3
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