Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | Cr2O7 |
| Molecular Weight | 215.988 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | -2 |
SHOW SMILES / InChI
SMILES
[O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O
InChI
InChIKey=SOCTUWSJJQCPFX-UHFFFAOYSA-N
InChI=1S/2Cr.7O/q;;;;;;;2*-1
| Molecular Formula | Cr2H2O7 |
| Molecular Weight | 218.0039 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Sodium dichromate is an inorganic compound, containing hexavalent chromium. It is highly corrosive and is a strong oxidizing agent. Sodium dichromate is mainly used to produce other chromium compounds but is also used in drilling muds, in metal treatments, in wood preservatives, in the production of dyes and organic chemicals and as a corrosion inhibitor. Sodium dichromate primarily affects the respiratory system causing ulcerations, shortness of breath, bronchitis, pneumonia, and asthma but can also affect the gastrointestinal tract, liver, kidneys and immune system. This substance is a known human carcinogen and is associated with an increased risk of developing lung cancer and cancer of the sinonasal cavity.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effects of Cr(VI) on the expression of the oxidative stress genes in human lung cells. | 1998 Aug |
|
| Inhibition of protein synthesis by chromium(VI) differentially affects expression of urokinase and its receptor in human type II pneumocytes. | 1999 Aug 1 |
|
| Differential effects of arsenic(III) and chromium(VI) on nuclear transcription factor binding. | 1999 Jul |
|
| Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase. | 2000 Jun 1 |
|
| Role of p53 tumor suppressor gene in the toxicity of TCDD, endrin, naphthalene, and chromium (VI) in liver and brain tissues of mice. | 2000 Mar 15 |
|
| The role of hydroxyl radical as a messenger in Cr(VI)-induced p53 activation. | 2000 Sep |
|
| LLU-alpha, an endogenous metabolite of gamma-tocopherol, is more effective against metal nephrotoxicity in rats than gamma-tocopherol. | 2001 Jul 6 |
|
| Chromium (VI)-induced oxidative stress, apoptotic cell death and modulation of p53 tumor suppressor gene. | 2001 Jun |
|
| Induction of apoptosis in the lung but not in the liver of rats receiving intra-tracheal instillations of chromium(VI). | 2002 Apr |
|
| Down-regulation of the DNA-repair endonuclease 8-oxo-guanine DNA glycosylase 1 (hOGG1) by sodium dichromate in cultured human A549 lung carcinoma cells. | 2002 Jan |
|
| Selective induction of gene expression in rat lung by hexavalent chromium. | 2002 Oct |
|
| Genomic and proteomic profiling of responses to toxic metals in human lung cells. | 2003 May |
|
| Interindividual variability in response to sodium dichromate-induced oxidative DNA damage: role of the Ser326Cys polymorphism in the DNA-repair protein of 8-oxo-7,8-dihydro-2'-deoxyguanosine DNA glycosylase 1. | 2005 Feb |
|
| NTP toxicity studies of sodium dichromate dihydrate (CAS No. 7789-12-0) administered in drinking water to male and female F344/N rats and B6C3F1 mice and male BALB/c and am3-C57BL/6 mice. | 2007 Jan |
|
| Identification of human cell responses to hexavalent chromium. | 2007 Oct |
|
| Comparison of the preventive effect of vitamin C and E on hexavalent chromium induced pulmonary fibrosis in rat. | 2008 Aug |
|
| Superoxide-mediated proteasomal degradation of Bcl-2 determines cell susceptibility to Cr(VI)-induced apoptosis. | 2008 Aug |
|
| Cr(VI) induces mitochondrial-mediated and caspase-dependent apoptosis through reactive oxygen species-mediated p53 activation in JB6 Cl41 cells. | 2010 Jun 1 |
|
| Nitric oxide-mediated bcl-2 stabilization potentiates malignant transformation of human lung epithelial cells. | 2010 May |
|
| Exposure to nickel, chromium, or cadmium causes distinct changes in the gene expression patterns of a rat liver derived cell line. | 2011 |
|
| Transcriptional responses in neonate and adult Daphnia magna in relation to relative susceptibility to genotoxicants. | 2011 Aug |
|
| The dual roles of c-Jun NH2-terminal kinase signaling in Cr(VI)-induced apoptosis in JB6 cells. | 2011 Feb |
|
| Hexavalent chromium inhibited the expression of RKIP of heart in vivo and in vitro. | 2011 Feb |
|
| Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium. | 2011 Sep |
|
| Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90days of exposure to hexavalent chromium in drinking water. | 2012 Feb 15 |
|
| Comparison of the effects of hexavalent chromium in the alimentary canal of F344 rats and B6C3F1 mice following exposure in drinking water: implications for carcinogenic modes of action. | 2012 Jan |
|
| Inhibitory effect of SJSZ glycoprotein (38 kDa) on expression of heat shock protein 27 and 70 in chromium (VI)-treated hepatocytes. | 2012 Jan |
|
| Comparative toxicogenomic analysis of oral Cr(VI) exposure effects in rat and mouse small intestinal epithelia. | 2012 Jul 15 |
|
| Long-term exposure to hexavalent chromium inhibits expression of tumor suppressor genes in cultured cells and in mice. | 2012 Jun |
|
| Whole adult organism transcriptional profiling of acute metal exposures in male zebrafish. | 2014 Mar 10 |
|
| Temporal changes in rat liver gene expression after acute cadmium and chromium exposure. | 2015 |
|
| Human bronchial epithelial BEAS-2B cells, an appropriate in vitro model to study heavy metals induced carcinogenesis. | 2015 Sep 15 |
|
| Hepatoprotective effect of Taraxacum officinale leaf extract on sodium dichromate-induced liver injury in rats. | 2016 Mar |
| Substance Class |
Chemical
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| Record UNII |
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| Record Status |
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