U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C21H24I3NO4.ClH
Molecular Weight 771.594
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of THYROMEDAN HYDROCHLORIDE

SMILES

Cl.CCN(CC)CCOC(=O)CC1=CC(I)=C(OC2=CC=C(OC)C(I)=C2)C(I)=C1

InChI

InChIKey=MNIDQQFSKKUQGQ-UHFFFAOYSA-N
InChI=1S/C21H24I3NO4.ClH/c1-4-25(5-2)8-9-28-20(26)12-14-10-17(23)21(18(24)11-14)29-15-6-7-19(27-3)16(22)13-15;/h6-7,10-11,13H,4-5,8-9,12H2,1-3H3;1H

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C21H24I3NO4
Molecular Weight 735.133
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Thyromedan is a thyroalkanoic acid derivative with hypocholesterolemic activity. In clinical trials, Thyromedan in daily doses of 8 to 32 mg caused a decrease in serum cholesterol levels. The serum total triglycerides and the α- and β-lipoprotein partition of cholesterol and triglycerides were unaffected.

Originator

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
THYROMIMETICS. I. THE SYNTHESIS AND HYPOCHOLESTEREMIC ACTIVITY OF SOME 3' AND 3',5'-ALKYL AND ARYL-3,5-DIIODOTHYRONINES.
1963 Sep
Serum lipids and glucose tolerance in diabetes during therapy with a thyromimetic agent.
1966 Jul-Aug
Patents

Patents

20060024365
8

Sample Use Guides

In Vivo Use Guide
8 to 32 mg/day
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:16:56 GMT 2023
Edited
by admin
on Fri Dec 15 15:16:56 GMT 2023
Record UNII
9L1802A75R
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
THYROMEDAN HYDROCHLORIDE
USAN  
USAN  
Official Name English
TYROMEDAN HYDROCHLORIDE
Common Name English
2-(Diethylamino)ethyl [3,5-diiodo-4-(3-iodo-4-methoxyphenoxy)phenyl]acetate hydrochloride
Systematic Name English
BENZENEACETIC ACID, 3,5-DIIODO-4-(3-IODO-4-METHOXYPHENOXY)-, 2-(DIETHYLAMINO)ETHYL ESTER, HYDROCHLORIDE
Common Name English
SK&F-13364-A
Code English
THYROMEDAN HYDROCHLORIDE [USAN]
Common Name English
THYROMEDAN HCL
Common Name English
SK&F 13364-A
Code English
Classification Tree Code System Code
NCI_THESAURUS C1553
Created by admin on Fri Dec 15 15:16:56 GMT 2023 , Edited by admin on Fri Dec 15 15:16:56 GMT 2023
Code System Code Type Description
FDA UNII
9L1802A75R
Created by admin on Fri Dec 15 15:16:56 GMT 2023 , Edited by admin on Fri Dec 15 15:16:56 GMT 2023
PRIMARY
EPA CompTox
DTXSID10205605
Created by admin on Fri Dec 15 15:16:56 GMT 2023 , Edited by admin on Fri Dec 15 15:16:56 GMT 2023
PRIMARY
ChEMBL
CHEMBL2111061
Created by admin on Fri Dec 15 15:16:56 GMT 2023 , Edited by admin on Fri Dec 15 15:16:56 GMT 2023
PRIMARY
NCI_THESAURUS
C80845
Created by admin on Fri Dec 15 15:16:56 GMT 2023 , Edited by admin on Fri Dec 15 15:16:56 GMT 2023
PRIMARY
CAS
57-65-8
Created by admin on Fri Dec 15 15:16:56 GMT 2023 , Edited by admin on Fri Dec 15 15:16:56 GMT 2023
PRIMARY
PUBCHEM
151112
Created by admin on Fri Dec 15 15:16:56 GMT 2023 , Edited by admin on Fri Dec 15 15:16:56 GMT 2023
PRIMARY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966