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Details

Stereochemistry ACHIRAL
Molecular Formula CH3FO2S
Molecular Weight 98.097
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of METHANESULFONYL FLUORIDE

SMILES

CS(F)(=O)=O

InChI

InChIKey=KNWQLFOXPQZGPX-UHFFFAOYSA-N
InChI=1S/CH3FO2S/c1-5(2,3)4/h1H3

HIDE SMILES / InChI

Molecular Formula CH3FO2S
Molecular Weight 98.097
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Methanesulfonyl fluoride (SNX 001), a very long-acting CNS-selective acetylcholinesterase inhibitor, was studied as a palliative treatment for senile dementia of the Alzheimer type. This drug successfully completed phase I clinical trials where it showed effectively enhance memory in patients with Alzheimer's disease. However, it appears that further studies were discontinued.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
In a randomized placebo-controlled phase I study, 3.6 mg, 7.2 mg or 10.8 mg methanesulfonyl fluoride (MSF) were then orally administered to 27 consenting healthy volunteers (aged 50 to 72 years).
Route of Administration: Oral
Substance Class Chemical
Record UNII
9H250YYY0R
Record Status Validated (UNII)
Record Version