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Details

Stereochemistry ACHIRAL
Molecular Formula CH3FO2S
Molecular Weight 98.097
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of METHANESULFONYL FLUORIDE

SMILES

CS(F)(=O)=O

InChI

InChIKey=KNWQLFOXPQZGPX-UHFFFAOYSA-N
InChI=1S/CH3FO2S/c1-5(2,3)4/h1H3

HIDE SMILES / InChI
Molecular Formula CH3FO2S
Molecular Weight 98.097
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Methanesulfonyl fluoride (SNX 001), a very long-acting CNS-selective acetylcholinesterase inhibitor, was studied as a palliative treatment for senile dementia of the Alzheimer type. This drug successfully completed phase I clinical trials where it showed effectively enhance memory in patients with Alzheimer's disease. However, it appears that further studies were discontinued.

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Acetylcholinesterase
207
Target ID: P22303|||Q53F46
Gene ID: 43.0
Gene Symbol: ACHE
Target Organism: Homo sapiens (Human)
Inhibitor
8297
PubMed

PubMed

TitleDatePubMed
Patents

Patents

04489094
1

Sample Use Guides

In Vivo Use Guide
In a randomized placebo-controlled phase I study, 3.6 mg, 7.2 mg or 10.8 mg methanesulfonyl fluoride (MSF) were then orally administered to 27 consenting healthy volunteers (aged 50 to 72 years).
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:11:06 GMT 2023
Edited
by admin
on Fri Dec 15 15:11:06 GMT 2023
Record UNII
9H250YYY0R
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
METHANESULFONYL FLUORIDE
Systematic Name English
MESYL FLUORIDE
Systematic Name English
SNX-001
Code English
FUMETTE
Brand Name English
Code System Code Type Description
CAS
558-25-8
Created by admin on Fri Dec 15 15:11:06 GMT 2023 , Edited by admin on Fri Dec 15 15:11:06 GMT 2023
PRIMARY
MESH
C005109
Created by admin on Fri Dec 15 15:11:06 GMT 2023 , Edited by admin on Fri Dec 15 15:11:06 GMT 2023
PRIMARY
PUBCHEM
11207
Created by admin on Fri Dec 15 15:11:06 GMT 2023 , Edited by admin on Fri Dec 15 15:11:06 GMT 2023
PRIMARY
EPA CompTox
DTXSID8060329
Created by admin on Fri Dec 15 15:11:06 GMT 2023 , Edited by admin on Fri Dec 15 15:11:06 GMT 2023
PRIMARY
WIKIPEDIA
METHANESULFONYL FLUORIDE
Created by admin on Fri Dec 15 15:11:06 GMT 2023 , Edited by admin on Fri Dec 15 15:11:06 GMT 2023
PRIMARY
DRUG BANK
DB13058
Created by admin on Fri Dec 15 15:11:06 GMT 2023 , Edited by admin on Fri Dec 15 15:11:06 GMT 2023
PRIMARY
FDA UNII
9H250YYY0R
Created by admin on Fri Dec 15 15:11:06 GMT 2023 , Edited by admin on Fri Dec 15 15:11:06 GMT 2023
PRIMARY
HSDB
6397
Created by admin on Fri Dec 15 15:11:06 GMT 2023 , Edited by admin on Fri Dec 15 15:11:06 GMT 2023
PRIMARY
ECHA (EC/EINECS)
209-192-2
Created by admin on Fri Dec 15 15:11:06 GMT 2023 , Edited by admin on Fri Dec 15 15:11:06 GMT 2023
PRIMARY
NIH
NCATS
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