Tecotabart vedotin

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 11:50:50 GMT 2025` Edited by `admin` on `Wed Apr 02 11:50:50 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	9GK5GYD8DQ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

LM-302

Preferred Name

English

Tecotabart vedotin

Official Name

English

TPX-4589

Code

English

Antibody drug conjugate composed of a humanized monoclonal antibody targeting CLDN18.2 and linker-payload MC-VC-PAB-MMAE

Common Name

English

H-gamma1 heavy chain humanized (1-449) [VH (Homo sapiens IGHV3-48*01 (88.8%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, G1v7 CH2 D3, E117 (CH1 K120 (216) (120-217), hi

Common Name

English

Immunoglobulin G1 [241-aspartic acid,334-glutamic acid], anti-(human/Mus musculus/Macaca/Rattus claudin CLDN18.2) (human-Mus musculus monoclonal LM-102 ?1-chain), disulfide with human-Mus musculus monoclonal LM-102 ?-chain, dimer, tetrakis(thioether) wit

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens CLDN18 (claudin 18, claudin-18, surfactant associated protein J, SFTPJ)], humanized monoclonal antibody; conjugated on an average of 4 cysteinyl residues via a cleavable linker to monomethylauristatin E (MMAE)

Common Name

English

tecotabart vedotin [INN]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

819021