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MIPOMERSEN
9GJ8S4GU0M
US Previously Marketed
First approved in 2013
General
Record Details
Names
5
Classification
5
Identifiers
18
Subunits
1
Sugars
2
Linkages
1
Relationships
1
Active Moiety
1
Modifications
1
Characteristic Attributes
1
MIPOMERSEN
9GJ8S4GU0M
US Previously Marketed
First approved in 2013
General
Approval Year
2013
596
Record Details
Substance Class
Nucleic Acid
Nucleic Acid Type
OLIGONUCLEOTIDE
Nucleic Acid Subtype
ANTI-SENSE
Sequence Origin
HUMAN
Sequence Type
COMPLETE
Record UNII
9GJ8S4GU0M
Record Status
Validated (UNII)
Record Version
17
16
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13
12
11
10
9
8
7
6
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4
3
2
1
Names
5
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5
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entries
Name
Type
Language
Name
Type
Language
MIPOMERSEN
Official Name
English
MIPOMERSEN [VANDF]
Common Name
English
mipomersen [INN]
Common Name
English
MIPOMERSEN [MI]
Common Name
English
Mipomersen [WHO-DD]
Common Name
English
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Classification
5
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entries
Classification Tree
Code System
Code
Classification Tree
Code System
Code
Designated/Approved
ORPHAN DRUG
Designated/Approved
Treatment of homozygous familial hypercholesterolemia
FDA ORPHAN DRUG
221406
Other lipid modifying agents
ATC
CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
Other lipid modifying agents
mipomersen
WHO-ATC
C10AX11
Established Pharmacologic Class
Established Pharmacologic Class
[EPC]
Apolipoprotein B-100 Synthesis Inhibitor
[EPC]
NDF-RT
N0000191627
Other lipid modifying agents
VATC
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
Other lipid modifying agents
mipomersen
WHO-VATC
QC10AX11
Established Pharmacologic Class
Established Pharmacologic Class
[EPC]
Antisense Oligonucleotide
[EPC]
NDF-RT
N0000191626
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Identifiers
18
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entries
Code System
Code
Type
Description
Code System
Code
Type
Description
DRUG CENTRAL
4747
PRIMARY
MESH
C524142
PRIMARY
ChEMBL
CHEMBL2219536
PRIMARY
INN
8946
PRIMARY
PUBCHEM
118984467
PRIMARY
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1
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Subunits
1
Subunit 0
>SUBUNIT_0
Sugars
2
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entries
Sugar
Site Range
Site Count
Sugar
Site Range
Site Count
2-O-beta-hydroxy-ethoxy-methyl Ribose (Qiagen)
1_1-1_5;1_16-1_20
10 / 20
Deoxyribose (DNA)
1_6-1_15
10 / 20
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Linkages
1
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entries
Linkage
Site Range
Site Count
Linkage
Site Range
Site Count
Phosporothioate
1_2-1_20
19 / 19
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Relationships
1
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entries
Related Record
Type
Details
Related Record
Type
Details
18EAY4870E
MIPOMERSEN SODIUM
SALT/SOLVATE -> PARENT
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Active Moiety
1
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entries
Related Record
Type
Details
Related Record
Type
Details
9GJ8S4GU0M
MIPOMERSEN
ACTIVE MOIETY
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Modifications
1
Structural Modifications
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entries
Modification Type
Location Site
Location Type
Residue Modified
Extent
Fragment Name
Fragment Approval
Modification Type
Location Site
Location Type
Residue Modified
Extent
Fragment Name
Fragment Approval
BASE SUBSTITUTION
[1_12] [1_15]
CYTOSINE
5-METHYLCYTOSINE
6R795CQT4H
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Characteristic Attributes
1
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entries
Name
Property Type
Amount
Referenced Substance
Defining
Parameters
References
Name
Property Type
Amount
Referenced Substance
Defining
Parameters
References
MOL_WEIGHT:CALCULATED
CHEMICAL
CALCULATED 6404 AMU (average)
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