9-HYDROXYELLIPTICINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H14N2O
Molecular Weight	262.3059
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C2C=CN=CC2=C(C)C3=C1NC4=C3C=C(O)C=C4

InChI

InChIKey=QZTWUDDGLIDXSE-UHFFFAOYSA-N

InChI=1S/C17H14N2O/c1-9-14-8-18-6-5-12(14)10(2)17-16(9)13-7-11(20)3-4-15(13)19-17/h3-8,19-20H,1-2H3

HIDE SMILES / InChI

Molecular Formula	C17H14N2O
Molecular Weight	262.3059
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription.	2013-02-15	23293027
Cytochrome b5 increases cytochrome P450 3A4-mediated activation of anticancer drug ellipticine to 13-hydroxyellipticine whose covalent binding to DNA is elevated by sulfotransferases and N,O-acetyltransferases.	2012-05-21	22390216
Tyrosine kinase inhibition: Ligand binding and conformational change in c-Kit and c-Abl.	2009-09-03	19660459
Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2.	2008-09	21218107
Cytochromes P450 reconstituted with NADPH: P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes.	2006-12	17159771
Oxidation pattern of the anticancer drug ellipticine by hepatic microsomes - similarity between human and rat systems.	2006-09	17197724
Development of a novel cytochrome p450 bioaffinity detection system coupled online to gradient reversed-phase high-performance liquid chromatography.	2005-08	16093552
The anticancer drug ellipticine forms covalent DNA adducts, mediated by human cytochromes P450, through metabolism to 13-hydroxyellipticine and ellipticine N2-oxide.	2004-11-15	15548707
9-hydroxyellipticine and derivatives as chemotherapy agents.	2003-03	12570841
Identification of new drug sensitivity genes using genetic suppressor elements: protein arginine N-methyltransferase mediates cell sensitivity to DNA-damaging agents.	2003-01-01	12517794
Cardioprotective effects of 9-hydroxyellipticine on ischemia and reperfusion in isolated rat heart.	2002-05	12083739
9-Hydroxyellipticine alters the conformation and DNA binding characteristics of mutated p53 protein.	2001-11-29	11724337

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:52:25 GMT 2025` Edited by `admin` on `Mon Mar 31 18:52:25 GMT 2025`
Record UNII	9G4A3ET6XG
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

9-HYDROXYELLIPTICINE

Common Name

English

NSC-210717

Preferred Name

English

9-HYDROXY-5,11-DIMETHYL-6H-PYRIDO(4,3-B)CARBAZOLE

Systematic Name

English

9-HYDROXYELLIPTICIN

Systematic Name

English

HYDROXYELLIPTICINE, 9-

Common Name

English

6H-PYRIDO(4,3-B)CARBAZOL-9-OL, 5,11-DIMETHYL-

Systematic Name

English

NSC-237070

Code

English

Code System Code Type Description

CAS

51131-85-2