Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C32H52O2 |
| Molecular Weight | 468.7541 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 10 / 10 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@H]1[C@@H]2[C@H]3CC[C@@H]4[C@@]5(C)CC[C@H](OC(C)=O)C(C)(C)[C@@H]5CC[C@@]4(C)[C@]3(C)CC[C@@]2(C)CCC1=C
InChI
InChIKey=SFEUTIOWNUGQMZ-ZHLOSDGBSA-N
InChI=1S/C32H52O2/c1-20-12-15-29(6)18-19-31(8)23(27(29)21(20)2)10-11-25-30(7)16-14-26(34-22(3)33)28(4,5)24(30)13-17-32(25,31)9/h21,23-27H,1,10-19H2,2-9H3/t21-,23-,24+,25-,26+,27-,29-,30+,31-,32-/m1/s1
| Molecular Formula | C32H52O2 |
| Molecular Weight | 468.7541 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 10 / 10 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Taraxasteryl acetate was identified as the major triterpenoid of the root bark of Scolymus hispanicus L. Antispasmodic. Taraxasterol acetate exhibits antiinflammatory activity. In mice ear edema (induced by phorbol-12-mirystate-13-acetate, croton oil, and arachidonic acid), taraxasteryl acetate showed a topical anti-inflammatory activity. Furthermore, it was found that taraxasteryl acetate has potent preventive activity against acute hepatic failure induced by P. acnes and LPS in a dose-dependent manner. There are also reports of a secondary effect of taraxasteryl acetate on the heat shock protein response.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Activity of taraxasteryl acetate on inflammation and heat shock protein synthesis. | 2005-04 |
|
| Antispasmodic and spasmogenic effects of Scolymus hispanicus and taraxasteryl acetate on isolated ileum preparation. | 1997-12 |
|
| Concerning the recently reassigned 13C-NMR spectrum of taraxasteryl acetate. | 1996-10 |
|
| Preventive effect of taraxasteryl acetate from Inula britannica subsp. japonica on experimental hepatitis in vivo. | 1995-02 |
Sample Use Guides
In mice ear edema (induced by phorbol-12-mirystate-13-acetate, croton oil and arachidonic acid), taraxasteryl acetate showed a topical anti-inflammatory activity similar to the extract, but at 1/20 of the dose.
Route of Administration:
Topical
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 20:37:39 GMT 2025
by
admin
on
Mon Mar 31 20:37:39 GMT 2025
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| Record UNII |
9F07Z33516
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| Record Status |
Validated (UNII)
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| Record Version |
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m10463
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