BELCESIRAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 10:50:35 GMT 2025` Edited by `admin` on `Wed Apr 02 10:50:35 GMT 2025`
Nucleic Acid Type	RNAI
Sequence Type	COMPLETE
Record UNII	9ET5DMZ3AW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BELCESIRAN

Official Name

English

DCR-A1AT

Preferred Name

English

DCR-S1459

Code

English

RNA, (AM-SP-AM-(2'-DEOXY-2'-FLUORO)A-CM-CM-CM-UM-(2'-DEOXY-2'-FLUORO)U-(2'-DEOXY-2'-FLUORO)U-(2'-DEOXY-2'-FLUORO)G-UM-(2'-DEOXY-2'-FLUORO)C-(2'-DEOXY-2'-FLUORO)U-UM-CM-UM-(2'-DEOXY-2'-FLUORO)U-AM-AM-AM-GM-CM-AM-GM-CM-CM-(2'-O-((2-(2-((5-((2-(ACETYLAMINO)

Common Name

English

BELCESIRAN [USAN]

Common Name

English

belcesiran [INN]

Common Name

English

Code System Code Type Description

INN

11754

Created by admin on Wed Apr 02 10:50:35 GMT 2025 , Edited by admin on Wed Apr 02 10:50:35 GMT 2025

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NCI_THESAURUS

C180639

Created by admin on Wed Apr 02 10:50:35 GMT 2025 , Edited by admin on Wed Apr 02 10:50:35 GMT 2025

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SMS_ID

100000184270

Created by admin on Wed Apr 02 10:50:35 GMT 2025 , Edited by admin on Wed Apr 02 10:50:35 GMT 2025

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FDA UNII

9ET5DMZ3AW

Created by admin on Wed Apr 02 10:50:35 GMT 2025 , Edited by admin on Wed Apr 02 10:50:35 GMT 2025

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CAS

2375562-54-0

Created by admin on Wed Apr 02 10:50:35 GMT 2025 , Edited by admin on Wed Apr 02 10:50:35 GMT 2025

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USAN

HI-177

Created by admin on Wed Apr 02 10:50:35 GMT 2025 , Edited by admin on Wed Apr 02 10:50:35 GMT 2025

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Sugar	Site Range	Site Count
D-Ribose (RNA)	1_27-1_30	4 / 58
2'-Fluoro-Ribose	1_3;1_8-1_10;1_12-1_13;1_17;2_2-2_3;2_5;2_7;2_12;2_14;2_16;2_19	15 / 58
2'-O-Methyl-Ribose	1_1-1_2;1_4-1_7;1_11;1_14-1_16;1_18-1_26;1_31-1_36;2_1;2_4;2_6;2_8-2_11;2_13;2_15;2_17-2_18;2_20-2_22	39 / 58

Linkage	Site Range	Site Count
Phosphate	1_3-1_36;2_5-2_20	50 / 56
Phosporothioate	1_2;2_2-2_4;2_21-2_22	6 / 56

Related Record Type Details


					9ET5DMZ3AW

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[2_1]	SITE_SPECIFIC			UNSPECIFIED SUBSTANCE	55513d6d (not in database)
NUCLEOSIDE_SUBSTITUTION	[1_27]	SITE_SPECIFIC			UNSPECIFIED SUBSTANCE	4b489b28 (not in database)
NUCLEOSIDE_SUBSTITUTION	[1_28] [1_29] [1_30]	SITE_SPECIFIC			UNSPECIFIED SUBSTANCE	3a625511 (not in database)