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Details

Stereochemistry RACEMIC
Molecular Formula C15H21N3O2S3.ClH
Molecular Weight 408.002
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AROTINOLOL HYDROCHLORIDE

SMILES

Cl.CC(C)(C)NCC(O)CSC1=NC(=CS1)C2=CC=C(S2)C(N)=O

InChI

InChIKey=XXDAXBZYUXLDRD-UHFFFAOYSA-N
InChI=1S/C15H21N3O2S3.ClH/c1-15(2,3)17-6-9(19)7-21-14-18-10(8-22-14)11-4-5-12(23-11)13(16)20;/h4-5,8-9,17,19H,6-7H2,1-3H3,(H2,16,20);1H

HIDE SMILES / InChI

Molecular Formula C15H21N3O2S3
Molecular Weight 371.541
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/6200619

Arotinolol (INN, marketed under the tradename Almarl) is a medication in the class of mixed alpha/beta blockers. It is used in the treatment of high blood pressure and essential tremor. The recommended dosage is 10–30 mg per day.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Synthesis and beta-adrenergic blocking action of a new thiazolylthiopropanolamine derivative.
1978 Sep
Arotinolol is a weak partial agonist on beta 3-adrenergic receptors in brown adipocytes.
2001 Jul
Clinical trial of arotinolol in the treatment of hypertension: dippers vs. non-dippers.
2001 Sep
Relapse of Graves' disease in a patient with pheochromocytoma.
2003 Dec
Pantothenate kinase-associated neurodegeneration initially presenting as postural tremor alone in a Japanese family with homozygous N245S substitutions in the pantothenate kinase gene.
2004 Oct 15
Effect of zonisamide on essential tremor: a pilot crossover study in comparison with arotinolol.
2005 Mar
Are adrenergic receptor blockers effective or contraindicated in pulmonary arterial hypertension?
2009 Dec
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec
Carteolol hydrochloride suppresses the generation of reactive oxygen species and rescues cell death after ultraviolet irradiation of cultured lens epithelial cells.
2010 Oct 12
Overview of essential tremor.
2010 Sep 7
Patents

Patents

Sample Use Guides

10-20 mg twice daily for 4 weeks
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:02:56 UTC 2023
Edited
by admin
on Fri Dec 15 17:02:56 UTC 2023
Record UNII
9DOI1HT306
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AROTINOLOL HYDROCHLORIDE
MART.   MI   WHO-DD  
Common Name English
AROTINOLOL HYDROCHLORIDE [MART.]
Common Name English
Arotinolol hydrochloride [WHO-DD]
Common Name English
AROTINOLOL HCL
Common Name English
AROTINOLOL HYDROCHLORIDE [JAN]
Common Name English
2-THIOPHENECARBOXAMIDE, 5-(2-((3-((1,1-DIMETHYLETHYL)AMINO)-2-HYDROXYPROPYL)THIO)-4-THIAZOLYL)-, MONOHYDROCHLORIDE, (±)-
Common Name English
(±)-2-(3'-TERT-BUTYLAMINO-2'-HYDROXYPROPYLTHIO)-4-(5'-CARBAMOYL-2'-THIENYL)THIAZOLE HCL
Common Name English
AROTINOLOL HYDROCHLORIDE [MI]
Common Name English
Code System Code Type Description
MERCK INDEX
m2052
Created by admin on Fri Dec 15 17:02:56 UTC 2023 , Edited by admin on Fri Dec 15 17:02:56 UTC 2023
PRIMARY Merck Index
PUBCHEM
155032
Created by admin on Fri Dec 15 17:02:56 UTC 2023 , Edited by admin on Fri Dec 15 17:02:56 UTC 2023
PRIMARY
EPA CompTox
DTXSID1046849
Created by admin on Fri Dec 15 17:02:56 UTC 2023 , Edited by admin on Fri Dec 15 17:02:56 UTC 2023
PRIMARY
MESH
C024523
Created by admin on Fri Dec 15 17:02:56 UTC 2023 , Edited by admin on Fri Dec 15 17:02:56 UTC 2023
PRIMARY
SMS_ID
100000085340
Created by admin on Fri Dec 15 17:02:56 UTC 2023 , Edited by admin on Fri Dec 15 17:02:56 UTC 2023
PRIMARY
FDA UNII
9DOI1HT306
Created by admin on Fri Dec 15 17:02:56 UTC 2023 , Edited by admin on Fri Dec 15 17:02:56 UTC 2023
PRIMARY
EVMPD
SUB00590MIG
Created by admin on Fri Dec 15 17:02:56 UTC 2023 , Edited by admin on Fri Dec 15 17:02:56 UTC 2023
PRIMARY
ChEMBL
CHEMBL93298
Created by admin on Fri Dec 15 17:02:56 UTC 2023 , Edited by admin on Fri Dec 15 17:02:56 UTC 2023
PRIMARY
CAS
68377-91-3
Created by admin on Fri Dec 15 17:02:56 UTC 2023 , Edited by admin on Fri Dec 15 17:02:56 UTC 2023
PRIMARY
Related Record Type Details
ENANTIOMER -> RACEMATE
RACEMATE -> ENANTIOMER
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY