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Details

Stereochemistry RACEMIC
Molecular Formula C29H34FN3O6.ClH
Molecular Weight 576.056
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Palonidipine hydrochloride

SMILES

Cl.COC(=O)C1=C(C)NC(C)=C(C1C2=C(F)C=CC(=C2)[N+]([O-])=O)C(=O)OCC(C)(C)CN(C)CC3=CC=CC=C3

InChI

InChIKey=OQHXRVQARZHYGQ-UHFFFAOYSA-N
InChI=1S/C29H34FN3O6.ClH/c1-18-24(27(34)38-6)26(22-14-21(33(36)37)12-13-23(22)30)25(19(2)31-18)28(35)39-17-29(3,4)16-32(5)15-20-10-8-7-9-11-20;/h7-14,26,31H,15-17H2,1-6H3;1H

HIDE SMILES / InChI
Molecular Formula C29H34FN3O6
Molecular Weight 539.5952
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Palonidipine (also known as TC 81) a calcium antagonist that was developed by Teijin for the treatment of hypertension and angina pectoris. Palonidipine was involved in phase II clinical trials in Japan. However, these studies were discontinued.

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
[Effect of palonidipine hydrochloride (TC-81), a new dihydropyridine derivative, on various myocardial ischemic models].
1993-08
[Effect of palonidipine hydrochloride (TC-81), a novel calcium antagonist, on the canine coronary artery].
1993-07
Patents

Patents

20070208029
8
20080167291
6
20120201891
2
Substance Class Chemical
Created
by admin
on Mon Mar 31 22:22:03 GMT 2025
Edited
by admin
on Mon Mar 31 22:22:03 GMT 2025
Record UNII
9D73PQ95UJ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TC-81
Preferred Name English
Palonidipine hydrochloride
Common Name English
3,5-Pyridinedicarboxylic acid, 4-(2-fluoro-5-nitrophenyl)-1,4-dihydro-2,6-dimethyl-, 3-[2,2-dimethyl-3-[methyl(phenylmethyl)amino]propyl] 5-methyl ester, hydrochloride (1:1)
Systematic Name English
3,5-Pyridinedicarboxylic acid, 4-(2-fluoro-5-nitrophenyl)-1,4-dihydro-2,6-dimethyl-, 2,2-dimethyl-3-[methyl(phenylmethyl)amino]propyl methyl ester, monohydrochloride
Systematic Name English
Code System Code Type Description
CAS
96515-74-1
Created by admin on Mon Mar 31 22:22:03 GMT 2025 , Edited by admin on Mon Mar 31 22:22:03 GMT 2025
PRIMARY
EPA CompTox
DTXSID5021099
Created by admin on Mon Mar 31 22:22:03 GMT 2025 , Edited by admin on Mon Mar 31 22:22:03 GMT 2025
PRIMARY
FDA UNII
9D73PQ95UJ
Created by admin on Mon Mar 31 22:22:03 GMT 2025 , Edited by admin on Mon Mar 31 22:22:03 GMT 2025
PRIMARY
PUBCHEM
119153
Created by admin on Mon Mar 31 22:22:03 GMT 2025 , Edited by admin on Mon Mar 31 22:22:03 GMT 2025
PRIMARY
NIH
NCATS
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