SPERMINE TETRAHYDROCHLORIDE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H26N4.4ClH
Molecular Weight	348.184
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of SPERMINE TETRAHYDROCHLORIDE

SMILES

Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN

InChI

InChIKey=XLDKUDAXZWHPFH-UHFFFAOYSA-N

InChI=1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H

HIDE SMILES / InChI

Molecular Formula	C10H26N4
Molecular Weight	202.3402
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count	MOL RATIO 4 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Targets

Primary Target	Pharmacology	Potency
Carbonic anhydrase IV 33	Inhibitor 8,297	10.0 nM [Ki]
Carbonic anhydrase VII 34	Inhibitor 8,297	710.0 nM [Ki]
Carbonic anhydrase VB 12	Inhibitor 8,297	830.0 nM [Ki]
Carbonic anhydrase VA 25	Inhibitor 8,297	840.0 nM [Ki]
Glutamate NMDA receptor 46	Activator 1,430	5.2 µM [EC50]

PubMed

Show entries

Title	Date	PubMed
Interactions of G(h)/transglutaminase with phospholipase Cdelta1 and with GTP.	1999 Oct 12	10518533
Spermine oxidation leads to necrosis with plasma membrane phosphatidylserine redistribution in mouse leukemia cells.	2000 Aug 25	10942576
Influence of heavy metals on the accumulation of trimethylglycine, putrescine and spermine in food plants.	2001	11354608
Amine oxidase, spermine, and hyperthermia induce cytotoxicity in P-glycoprotein overexpressing multidrug resistant Chinese hamster ovary cells.	2001	11310564
Transport and metabolism of agmatine in rat hepatocyte cultures.	2001 Feb	11179960

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Patents

Substance Class	Chemical
Record UNII	9CI1570O48
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

SPERMINE TETRAHYDROCHLORIDE

Systematic Name

English

SPERMINE TETRAHYDROCHLORIDE [MI]

Common Name

English

SPERMINE HYDROCHLORIDE

Systematic Name

English

N1,N4-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE TETRAHYDROCHLORIDE

Systematic Name

English

N,N'-BIS(3-AMINOPROPYL)TETRAMETHYLENEDIAMINE TETRAHYDROCHLORIDE

Systematic Name

English

Showing 1 to 5 of 7 entries

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Code System

Code

Type

Description

EPA CompTox

DTXSID0059792

PRIMARY

CAS

306-67-2

PRIMARY

FDA UNII

9CI1570O48

PRIMARY

NSC

69852

PRIMARY

PUBCHEM

9384

PRIMARY

Showing 1 to 5 of 7 entries

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