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Details

Stereochemistry ACHIRAL
Molecular Formula C10H26N4.4ClH
Molecular Weight 348.1841
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SPERMINE TETRAHYDROCHLORIDE

SMILES

C(CCNCCCN)CNCCCN.Cl.Cl.Cl.Cl

InChI

InChIKey=XLDKUDAXZWHPFH-UHFFFAOYSA-N
InChI=1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H

HIDE SMILES / InChI

Molecular Formula C10H26N4
Molecular Weight 202.3406
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.4609
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Targets
PubMed

PubMed

TitleDatePubMed
Influence of heavy metals on the accumulation of trimethylglycine, putrescine and spermine in food plants.
2001
Polyamines of the thermophilic eubacteria belonging to the genera Thermosipho, Thermaerobacter and Caldicellulosiruptor.
2001
Amine oxidase, spermine, and hyperthermia induce cytotoxicity in P-glycoprotein overexpressing multidrug resistant Chinese hamster ovary cells.
2001
Polyamines of the hyperthermophilic archaebacteria belonging to the genera Thermococcus and Methanothermus and two new genera Caldivirga and Palaeococcus.
2001
Phase 1 study of N1-N11-diethylnorspermine (DENSPM) administered TID for 6 days in patients with advanced malignancies.
2001
Possible implications of arginase and diamine oxidase in prostatic carcinoma.
2001
Intestinal ornithine decarboxylase in short bowel syndrome patients with oral diet.
2001 Apr
5-Methoxysalicylic acid and spermine: a new matrix for the matrix-assisted laser desorption/ionization mass spectrometry analysis of oligonucleotides.
2001 Apr
Transgenic manipulation of the metabolism of polyamines in poplar cells.
2001 Apr
Effect of polyamine depletion on caspase activation: a study with spermine synthase-deficient cells.
2001 Apr 1
Effect of the interaction between a low tyramine-producing Lactobacillus and proteolytic staphylococci on biogenic amine production during ripening and storage of dry sausages.
2001 Apr 11
Involvement of polyamines in B cell receptor-mediated apoptosis: spermine functions as a negative modulator.
2001 Apr 15
Heme oxygenase-1 induction by nitric oxide in RAW 264.7 macrophages is upregulated by a cyclo-oxygenase-2 inhibitor.
2001 Apr 3
Non-destructive quantitation of spermine in human prostate tissue samples using HRMAS 1H NMR spectroscopy at 9.4 T.
2001 Apr 6
Regional distribution of ornithine decarboxylase activity and polyamine levels in experimental cat brain tumors.
2001 Aug
Reaction of superoxide and nitric oxide with peroxynitrite. Implications for peroxynitrite-mediated oxidation reactions in vivo.
2001 Aug 3
Methyl jasmonate upregulates biosynthetic gene expression, oxidation and conjugation of polyamines, and inhibits shoot formation in tobacco thin layers.
2001 Feb
Biogenic amines in vacuum-packaged and carbon dioxide-controlled atmosphere-packaged fresh pork stored at -1.50 degrees C.
2001 Feb
Radioligand binding assays in the drug discovery process: potential pitfalls of high throughput screenings.
2001 Feb
Enhancement of gene delivery by an analogue of alpha-MSH in a receptor-independent fashion.
2001 Feb 9
Phosphodiester and phosphorothioate oligonucleotide condensation and preparation of antisense nanoparticles.
2001 Jan 12
Genetic analysis of spermidine synthase from Leishmania donovani.
2001 Jul
Polyamine metabolism in brain tumours: diagnostic relevance of quantitative biochemistry.
2001 Jul
Polyamine depletion arrests growth of IEC-6 and Caco-2 cells by different mechanisms.
2001 Jul
Occurrence of cadaverine in hairy roots of Brugmansia candida.
2001 Jul
Agmatine and putrescine uptake in the human glioma cell line SK-MG-1.
2001 Jun
Permeability characteristics of polyamines across intestinal epithelium using the Caco-2 monolayer system: comparison between transepithelial flux and mitogen-stimulated uptake into epithelial cells.
2001 Jun
Importance of the 3' untranslated region of ornithine decarboxylase mRNA in the translational regulation of the enzyme.
2001 Jun 1
Different roles of spermine in glucocorticoid- and Fas-induced apoptosis.
2001 Jun 10
Chemistry of the diazeniumdiolates. 2. Kinetics and mechanism of dissociation to nitric oxide in aqueous solution.
2001 Jun 13
Translocon pores in the endoplasmic reticulum are permeable to a neutral, polar molecule.
2001 Jun 22
Effects of two photoreactive spermine analogues on peptide bond formation and their application for labeling proteins in Escherichia coli functional ribosomal complexes.
2001 Jun 26
Determination of polyamines in human saliva by high-performance liquid chromatography with fluorescence detection.
2001 Jun 5
Polyamines secreted by cancer cells possibly account for the impairment of the human erythrocyte sodium pump activity.
2001 Mar
X-ray crystallographic observation of "in-line" and "adjacent" conformations in a bulged self-cleaving RNA/DNA hybrid.
2001 Mar
Investigation of the ternary D-myo-inositol 1,2,6-tris(phosphate)-spermine-Zn2+ system in solution.
2001 Mar
Increased expression of NR2A subunit does not alter NMDA-evoked responses in cultured fetal trisomy 16 mouse hippocampal neurons.
2001 Mar
Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channel.
2001 Mar 15
Polyamine cytotoxicity in the presence of bovine serum amine oxidase.
2001 Mar 23
Regulation of estrogenic and nuclear factor kappa B functions by polyamines and their role in polyamine analog-induced apoptosis of breast cancer cells.
2001 Mar 29
Chemoprevention by difluoromethylornithine: correlation of an in vitro human cell assay with human clinical data for biomarker modulation.
2001 Mar-Apr
Inactivation of catalase and superoxide dismutase by singlet oxygen derived from photoactivated dye.
2001 May
A spermine-coupled cholesterol metabolite from the shark with potent appetite suppressant and antidiabetic properties.
2001 May
Inhibition of Na+,K+-ATPase by interferon gamma down-regulates intestinal epithelial transport and barrier function.
2001 May
NF-kappaB activation and susceptibility to apoptosis after polyamine depletion in intestinal epithelial cells.
2001 May
A clinical inflammatory syndrome attributable to aerosolized lipid-DNA administration in cystic fibrosis.
2001 May 1
Spermine supports catalysis of hairpin ribozyme variants to differing extents.
2001 May 11
Spermine: an "invisible" component in the crystals of B-DNA. A grand canonical Monte Carlo and molecular dynamics simulation study.
2001 May 18
Polyamines in the basal ganglia of human brain. Influence of aging and degenerative movement disorders.
2001 May 18
Polyamine synthesis and interconversion by the Microsporidian Encephalitozoon cuniculi.
2001 May-Jun
Patents
Substance Class Chemical
Created
by admin
on Sat Jun 26 00:07:44 UTC 2021
Edited
by admin
on Sat Jun 26 00:07:44 UTC 2021
Record UNII
9CI1570O48
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SPERMINE TETRAHYDROCHLORIDE
MI  
Systematic Name English
SPERMINE TETRAHYDROCHLORIDE [MI]
Common Name English
SPERMINE HYDROCHLORIDE
Systematic Name English
N1,N4-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE TETRAHYDROCHLORIDE
Systematic Name English
N,N'-BIS(3-AMINOPROPYL)TETRAMETHYLENEDIAMINE TETRAHYDROCHLORIDE
Systematic Name English
NSC-69852
Code English
1,4-BUTANEDIAMINE, N1,N4-BIS(3-AMINOPROPYL)-, HYDROCHLORIDE (1:4)
Systematic Name English
Code System Code Type Description
EPA CompTox
306-67-2
Created by admin on Sat Jun 26 00:07:44 UTC 2021 , Edited by admin on Sat Jun 26 00:07:44 UTC 2021
PRIMARY
CAS
306-67-2
Created by admin on Sat Jun 26 00:07:44 UTC 2021 , Edited by admin on Sat Jun 26 00:07:44 UTC 2021
PRIMARY
FDA UNII
9CI1570O48
Created by admin on Sat Jun 26 00:07:44 UTC 2021 , Edited by admin on Sat Jun 26 00:07:44 UTC 2021
PRIMARY
PUBCHEM
9384
Created by admin on Sat Jun 26 00:07:44 UTC 2021 , Edited by admin on Sat Jun 26 00:07:44 UTC 2021
PRIMARY
MERCK INDEX
M10140
Created by admin on Sat Jun 26 00:07:44 UTC 2021 , Edited by admin on Sat Jun 26 00:07:44 UTC 2021
PRIMARY Merck Index
ECHA (EC/EINECS)
206-189-8
Created by admin on Sat Jun 26 00:07:44 UTC 2021 , Edited by admin on Sat Jun 26 00:07:44 UTC 2021
PRIMARY