Persicabtagene Lemgedleucel

Investigational

Approval Year

Substance Class	Structurally Diverse
Source Materials Class	ORGANISM
Source Materials Type	ALLOGENIC HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Name	cd4+/cd8+ t cells
Record UNII	9C6AT9DSU2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

allogeneic CD4+/CD8+ T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis of healthy donors, transduced with a lentiviral vector to overexpress CD47 and a CD19-directed chimeric antigen receptor (CAR). The cells have also been

Preferred Name

English

Persicabtagene Lemgedleucel

Official Name

English

persicabtagene lemgedleucel [INN]

Common Name

English

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Code System

Code

Type

Description

FDA UNII

9C6AT9DSU2

PRIMARY

NCI_THESAURUS

C211697

PRIMARY

INN

13136

PRIMARY

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Related Record

Type

Details


					9C6AT9DSU2

Persicabtagene Lemgedleucel

ACTIVE MOIETY

Amount:

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Agent Modifications

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Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
CRISPR	GENE EDITING	GENE MODIFICATION	Cas12b mRNA and sgRNAs are combined for the electroporation in a multiplex approach	Persicabtagene lemgedleucel sgRNA targeting B2M locus	95YRJ2A5AD
ELECTROPORATION	GENE EDITING	GENE MODIFICATION		UNSPECIFIED SUBSTANCE	b87e4e3d
CRISPR	GENE EDITING	GENE MODIFICATION	Cas12b mRNA and sgRNAs are combined for the electroporation in a multiplex approach	Persicabtagene lemgedleucel sgRNA targeting TRAC locus	J5PZ6ZT8TB
CULTURE	ACTIVATOR	BIOLOGICAL		ANTI-CD3/ANTI-CD28 4.5 MICRON MAGNETIC BEADS	PA28ZKP50M
CRISPR	GENE EDITING	GENE MODIFICATION	Cas12b mRNA and sgRNAs are combined for the electroporation in a multiplex approach	Persicabtagene lemgedleucel sgRNA targeting CIITA locus	69QP5QX83X

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Structural Modifications

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Modification Type	Location Type	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN		Persicabtagene lemgedleucel expressed anti-CD19 chimeric antigen receptor (CAR) and CD47	5E5TJ823Q3
PROTEIN NOT EXPRESSED (GENE DISRUPTION)	Target exon 2	Beta-2-microglobulin	ZVJ2Y47NLW
VECTOR EXPRESSED PROTEIN		LEUKOCYTE SURFACE ANTIGEN CD47	90DHW5TM9S
VECTOR EXPRESSED PROTEIN		Persicabtagene lemgedleucel expressed anti-CD19 chimeric antigen receptor (CAR)	HZ2LH72E5C
VECTOR EXPRESSED PROTEIN		UNSPECIFIED SUBSTANCE	6b38ac2e (not in database)

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