U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Wed Apr 02 19:47:18 GMT 2025
Edited
by admin
on Wed Apr 02 19:47:18 GMT 2025
Source Materials Class ORGANISM
Source Materials Type ALLOGENIC HUMAN
Source Materials State LIVE GENETICALLY MODIFIED
Source Materials Parent
Part blood
Fraction Name cd4+/cd8+ t cells
Record UNII
9C6AT9DSU2
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
allogeneic CD4+/CD8+ T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis of healthy donors, transduced with a lentiviral vector to overexpress CD47 and a CD19-directed chimeric antigen receptor (CAR). The cells have also been
Preferred Name English
Persicabtagene Lemgedleucel
INN  
Official Name English
persicabtagene lemgedleucel [INN]
Common Name English
Code System Code Type Description
FDA UNII
9C6AT9DSU2
Created by admin on Wed Apr 02 19:47:18 GMT 2025 , Edited by admin on Wed Apr 02 19:47:18 GMT 2025
PRIMARY
NCI_THESAURUS
C211697
Created by admin on Wed Apr 02 19:47:18 GMT 2025 , Edited by admin on Wed Apr 02 19:47:18 GMT 2025
PRIMARY
INN
13136
Created by admin on Wed Apr 02 19:47:18 GMT 2025 , Edited by admin on Wed Apr 02 19:47:18 GMT 2025
PRIMARY
Related Record Type Details
ACTIVE MOIETY

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID
CRISPR GENE EDITING GENE MODIFICATION Persicabtagene lemgedleucel sgRNA targeting B2M locus 95YRJ2A5AD
ELECTROPORATION GENE EDITING GENE MODIFICATION UNSPECIFIED SUBSTANCE b87e4e3d
CRISPR GENE EDITING GENE MODIFICATION Persicabtagene lemgedleucel sgRNA targeting TRAC locus J5PZ6ZT8TB
CULTURE ACTIVATOR BIOLOGICAL ANTI-CD3/ANTI-CD28 4.5 MICRON MAGNETIC BEADS PA28ZKP50M
CRISPR GENE EDITING GENE MODIFICATION Persicabtagene lemgedleucel sgRNA targeting CIITA locus 69QP5QX83X
CULTURE ACTIVATOR BIOLOGICAL ALDESLEUKIN M89N0Q7EQR
LENTIVIRAL TRANSFECTION TRANSFECTION Persicabtagene lemgedleucel Lentiviral vector 773TSQ48SW

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR EXPRESSED PROTEIN Persicabtagene lemgedleucel expressed anti-CD19 chimeric antigen receptor (CAR) and CD47 5E5TJ823Q3
PROTEIN NOT EXPRESSED (GENE DISRUPTION) Target exon 2 Beta-2-microglobulin ZVJ2Y47NLW
VECTOR EXPRESSED PROTEIN LEUKOCYTE SURFACE ANTIGEN CD47 90DHW5TM9S
VECTOR EXPRESSED PROTEIN Persicabtagene lemgedleucel expressed anti-CD19 chimeric antigen receptor (CAR) HZ2LH72E5C
VECTOR EXPRESSED PROTEIN UNSPECIFIED SUBSTANCE
6b38ac2e
(not in database)
INSERTED GENE EXPRESSION VECTOR Persicabtagene lemgedleucel transgene insert as DNA RGC4YF6RSP
PROTEIN NOT EXPRESSED (GENE DISRUPTION) Target exon 3 T CELL RECEPTOR ALPHA CHAIN CONSTANT 782D7EP5JS
PROTEIN NOT EXPRESSED (GENE DISRUPTION) Target exon 3 MHC CLASS II TRANSACTIVATOR DLF83EK1PC