TEPHROSIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H22O7
Molecular Weight	410.4166
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC2=C(C=C1OC)[C@@]3(O)[C@@H](CO2)OC4=C(C=CC5=C4C=CC(C)(C)O5)C3=O

InChI

InChIKey=AQBZCCQCDWNNJQ-AUSIDOKSSA-N

InChI=1S/C23H22O7/c1-22(2)8-7-12-15(30-22)6-5-13-20(12)29-19-11-28-16-10-18(27-4)17(26-3)9-14(16)23(19,25)21(13)24/h5-10,19,25H,11H2,1-4H3/t19-,23-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C23H22O7
Molecular Weight	410.4166
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Tephrosin-induced autophagic cell death in A549 non-small cell lung cancer cells.	2010-11	21061222
Rotenoids from Lablab purpureus L. and their bioefficacy against human disease vectors.	2010-11	20803155
Concise modular asymmetric synthesis of deguelin, tephrosin and investigation into their mode of action.	2010-08-23	20572190
Natural toxins for use in pest management.	2010-08	22069667
Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells.	2010-07-15	20630104
Tephrosin induces internalization and degradation of EGFR and ErbB2 in HT-29 human colon cancer cells.	2010-07-01	20056314
Optimising resolution for a preparative separation of Chinese herbal medicine using a surrogate model sample system.	2009-06-26	19447397
Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression.	2008-10	18841906
Phthalides from Pittosporum illicioides var. illicioides with inhibitory activity on superoxide generation and elastase release by neutrophils.	2008-10	18817445
Preparative isolation and purification of three rotenoids and one isoflavone from the seeds of Millettia pachycarpa Benth by high-speed counter-current chromatography.	2008-01-18	18082754
[Rotenoids from Derris trifoliata].	2007-06	17918433
Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa.	2007-02-01	17158054
Two unusual rotenoid derivatives, 7a-O-methyl-12a-hydroxydeguelol and spiro-13-homo-13-oxaelliptone, from the seeds of Derris trifoliata.	2006-05	16483619
Cytotoxic compounds from Mundulea chapelieri from the Madagascar Rainforest.	2004-03	15043430
Rotenone and rotenoids in cubè resins, formulations, and residues on olives.	2004-01-28	14733510
Effect of rotenoids from the seeds of Millettia dura on larvae of Aedes aegypti.	2003-10	14561074

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:43:52 GMT 2025` Edited by `admin` on `Mon Mar 31 22:43:52 GMT 2025`
Record UNII	9C081V83CC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TEPHROSIN

Common Name

English

DEGUELINOL I

Preferred Name

English

TEPHROSIN [MI]

Common Name

English

HYDROXYDEGUELIN

Common Name

English

3H-BIS(1)BENZOPYRANO(3,4-B:6',5'-E)PYRAN-7(7AH)-ONE, 13,13A-DIHYDRO-7A-HYDROXY-9,10-DIMETHOXY-3,3-DIMETHYL-, (7AR,13AR)-

Systematic Name

English

TOXICAROL

Common Name

English

Code System Code Type Description

CHEBI

9442