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Details

Stereochemistry UNKNOWN
Molecular Formula C17H18FN3S
Molecular Weight 315.408
Optical Activity ( + )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TIMELOTEM, (+)-

SMILES

CN1CCN2C(C1)CN=C(C3=CC=CS3)C4=C2C=C(F)C=C4

InChI

InChIKey=ICHHTOMWWAMJQP-UHFFFAOYSA-N
InChI=1S/C17H18FN3S/c1-20-6-7-21-13(11-20)10-19-17(16-3-2-8-22-16)14-5-4-12(18)9-15(14)21/h2-5,8-9,13H,6-7,10-11H2,1H3

HIDE SMILES / InChI

Molecular Formula C17H18FN3S
Molecular Weight 315.408
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Timelotem is a benzodiazepine derivative patented by Kali-Chemie Pharma G.m.b.H. as an anesthetic agent. In preclinical models, Timelotem shows atypical antipsychotic activity. Timelotem antagonizes DL-2-amino-5-phosphonovaleric acid (AP-5)-induced sniffing and the body turns in rats. Further, Timelotem antagonized amphetamine-induced stereotyped behavior in rats but was found less active than haloperidol in this test.

Approval Year

PubMed

PubMed

TitleDatePubMed
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 16 10:15:03 GMT 2023
Edited
by admin
on Sat Dec 16 10:15:03 GMT 2023
Record UNII
9B2BQO7LIL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TIMELOTEM, (+)-
Common Name English
PYRAZINO(1,2-A)(1,4)BENZODIAZEPINE, 10-FLUORO-1,2,3,4,4A,5-HEXAHYDRO-3-METHYL-7-(2-THIENYL)-, (+)-
Systematic Name English
Code System Code Type Description
CAS
120106-97-0
Created by admin on Sat Dec 16 10:15:03 GMT 2023 , Edited by admin on Sat Dec 16 10:15:03 GMT 2023
PRIMARY
FDA UNII
9B2BQO7LIL
Created by admin on Sat Dec 16 10:15:03 GMT 2023 , Edited by admin on Sat Dec 16 10:15:03 GMT 2023
PRIMARY
PUBCHEM
65844
Created by admin on Sat Dec 16 10:15:03 GMT 2023 , Edited by admin on Sat Dec 16 10:15:03 GMT 2023
PRIMARY