Umedaptanib Pegol

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 15:10:44 GMT 2023` Edited by `admin` on `Sat Dec 16 15:10:44 GMT 2023`
Nucleic Acid Type	APTAMER
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	9A7W6PH8PV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Umedaptanib Pegol

Official Name

English

umedaptanib pegol [INN]

Common Name

English

RNA, (Gm-Gm-Gm-Am-Um-Am-Cm-(2′-deoxy-2′-fluoro)U-Am-Gm-Gm-G-Cm-Am-Um-(2′-deoxy-2′-fluoro)U-Am-Am-Um-Gm-(2′-deoxy-2′-fluoro)U-Um-Am-Cm-Cm-Am-G-(2′-deoxy-2′-fluoro)U-G-(2′-deoxy-2′-fluoro)U-Am-Gm-Um-Cm-Cm-Cm-(3′→3′)-dT), 5′-[6-[

Common Name

English

Code System Code Type Description

FDA UNII

9A7W6PH8PV

Created by admin on Sat Dec 16 15:10:44 GMT 2023 , Edited by admin on Sat Dec 16 15:10:44 GMT 2023

PRIMARY

INN

12453

Created by admin on Sat Dec 16 15:10:44 GMT 2023 , Edited by admin on Sat Dec 16 15:10:44 GMT 2023

PRIMARY

NCI_THESAURUS

C199123

Created by admin on Sat Dec 16 15:10:44 GMT 2023 , Edited by admin on Sat Dec 16 15:10:44 GMT 2023

PRIMARY

CAS

2734771-59-4

Created by admin on Sat Dec 16 15:10:44 GMT 2023 , Edited by admin on Sat Dec 16 15:10:44 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	1_1-1_7;1_9-1_11;1_13-1_15;1_17-1_20;1_22-1_26;1_31-1_36	28 / 37
2'-Fluoro-Ribose	1_8;1_16;1_21;1_28;1_30	5 / 37
D-Ribose (RNA)	1_12;1_27;1_29	3 / 37
Deoxyribose (DNA)	1_37	1 / 37

Linkage	Site Range	Site Count
Phosphate	1_1-1_36	36 / 36

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					9A7W6PH8PV

Umedaptanib Pegol

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS			Branched PEG-450-C6-amino linker-guanosine 5'-monophosphate	2WDC92Q7GB
NUCLEOTIDE SUBSTITUTION	[1_37]	3'-TERMINUS			THYMIDINE 3'-MONOPHOSPHATE	Q84LAH3NDH