Umedaptanib Pegol

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 04:33:17 GMT 2025` Edited by `admin` on `Wed Apr 02 04:33:17 GMT 2025`
Nucleic Acid Type	APTAMER
Sequence Type	COMPLETE
Record UNII	9A7W6PH8PV
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Umedaptanib Pegol

Official Name

English

RNA, (Gm-Gm-Gm-Am-Um-Am-Cm-(2?-deoxy-2?-fluoro)U-Am-Gm-Gm-G-Cm-Am-Um-(2?-deoxy-2?-fluoro)U-Am-Am-Um-Gm-(2?-deoxy-2?-fluoro)U-Um-Am-Cm-Cm-Am-G-(2?-deoxy-2?-fluoro)U-G-(2?-deoxy-2?-fluoro)U-Am-Gm-Um-Cm-Cm-Cm-(3??3?)-dT), 5?-[6-[[(2,3-dihydroxypropoxy)carbo

Preferred Name

English

umedaptanib pegol [INN]

Common Name

English

Code System Code Type Description

FDA UNII

9A7W6PH8PV

Created by admin on Wed Apr 02 04:33:17 GMT 2025 , Edited by admin on Wed Apr 02 04:33:17 GMT 2025

PRIMARY

SMS_ID

300000052737

Created by admin on Wed Apr 02 04:33:17 GMT 2025 , Edited by admin on Wed Apr 02 04:33:17 GMT 2025

PRIMARY

INN

12453

Created by admin on Wed Apr 02 04:33:17 GMT 2025 , Edited by admin on Wed Apr 02 04:33:17 GMT 2025

PRIMARY

NCI_THESAURUS

C199123

Created by admin on Wed Apr 02 04:33:17 GMT 2025 , Edited by admin on Wed Apr 02 04:33:17 GMT 2025

PRIMARY

CAS

2734771-59-4

Created by admin on Wed Apr 02 04:33:17 GMT 2025 , Edited by admin on Wed Apr 02 04:33:17 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	1_1-1_7;1_9-1_11;1_13-1_15;1_17-1_20;1_22-1_26;1_31-1_36	28 / 37
2'-Fluoro-Ribose	1_8;1_16;1_21;1_28;1_30	5 / 37
D-Ribose (RNA)	1_12;1_27;1_29	3 / 37
Deoxyribose (DNA)	1_37	1 / 37

Linkage	Site Range	Site Count
Phosphate	1_1-1_36	36 / 36

Related Record Type Details


					S3529G9M9V

BASIC FIBROBLAST GROWTH FACTOR (HUMAN)

TARGET -> INHIBITOR

Amount:


					057L1JHV6Z

FIBROBLAST GROWTH FACTOR 2 HOMODIMER

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					9A7W6PH8PV

Umedaptanib Pegol

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS			Branched PEG-450-C6-amino linker-guanosine 5'-monophosphate	2WDC92Q7GB
NUCLEOTIDE SUBSTITUTION	[1_37]	3'-TERMINUS			THYMIDINE 3'-MONOPHOSPHATE	Q84LAH3NDH