FONTURACETAM

Investigational

Details

Stereochemistry	RACEMIC
Molecular Formula	C12H14N2O2
Molecular Weight	218.2518
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

NC(=O)CN1CC(CC1=O)C2=CC=CC=C2

InChI

InChIKey=LYONXVJRBWWGQO-UHFFFAOYSA-N

InChI=1S/C12H14N2O2/c13-11(15)8-14-7-10(6-12(14)16)9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,13,15)

HIDE SMILES / InChI

Molecular Formula	C12H14N2O2
Molecular Weight	218.2518
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description

Fonturacetam, also known as Phenylpiracetam, is marketed in Russia as Carphedon and Phenotropil. It is one of the first ever nootropic drugs and originally discovered in Russia. Fonturacetam acts on most neurotransmitter systems and has been used for its cognitive and physical enhancing properties, and also as an antidepressant.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Nicotinic acetylcholine receptor alpha6/alpha3/beta2/beta3 1	Antagonist 2,778		5.8 µM [IC50]

Conditions

Condition	Modality	Highest Phase	Product
Memory enhancement 1	Primary	Not Provided 504	phenotropil
Organic brain lesions 1	Primary	Not Provided 504	phenotropil
Epilepsy 121	Primary	Not Provided 504	phenotropil
Depression 235	Primary	Not Provided 504	phenotropil
Rehabilitation of stroke 1	Primary	Not Provided 504	phenotropil

PubMed

Title	Date	PubMed
No data available in table

Patents

Sample Use Guides

In Vivo Use Guide

A Russian manufacturer of Phenotropil recommends 100 mg per day.

Route of Administration: Oral

In Vitro Use Guide

In vitro, phenotropil (IC50 = 5.86 μM) directly influenced α4β2 nicotinic acetylcholine receptors in the mouse brain cortex.

Substance Class	Chemical
Record UNII	99QW5JU66Y
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

FONTURACETAM

Official Name

English

(R,S)-2-(2-OXO-4-PHENYLPYRROLIDIN-1-YL)ACETAMIDE

Systematic Name

English

RAC-2-((4R)-2-OXO-4-PHENYLPYROLIDIN-1-YL)ACETAMIDE

Common Name

English

PHENYLPIRACETAM

Common Name

English

4-Phenylpiracetam [WHO-DD]

Common Name

English

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Classification Tree

Code System

Code

Protective Agent

NCI_THESAURUS

C1509

other

DSLD

4049 (Number of products:6)

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Code System

Code

Type

Description

INN

9111

PRIMARY

PUBCHEM

132441

PRIMARY

NCI_THESAURUS

C96852

PRIMARY

EPA CompTox

DTXSID30868438

PRIMARY

MANUFACTURER PRODUCT INFORMATION

FONTURACETAM

PRIMARY

Phenylpiracetam is one of the most peculiar and stimulating nootropics currently available, it has effects very similar to stacking Adderall and piracetam. Due to its added Phenyl group, it influences dopamine receptors in the brain, and therefore carries much the same effect. It also targets memory, focus and overall brain health, phenylpiraceatm is bar none one of my favorite nootropics for these reasons, it is available in 90 capsules as well as a cheaper sampler pack version.

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