Zubotamig

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 10:09:00 GMT 2025` Edited by `admin` on `Wed Apr 02 10:09:00 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	IGG1
Sequence Type	COMPLETE
Record UNII	99MWR4VJT2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Immunoglobulin G1 [101-glycine,234-phenylalanine,235-glutamic acid,265-alanine,405-leucine,de-C-terminal-lysine], anti-(human CD3 antigen) (human-Mus musculus monoclonal IgG1-huCACAO-H101G-FEAL ?1-chain), disulfide with human-Mus musculus monoclonal IgG1

Preferred Name

English

Zubotamig

Official Name

English

immunoglobulin (H-gamma1_L-kappa)_(H-gamma1_L-lambda2), anti-[Homo sapiens VTCN1 (V-set domain containing T cell activation inhibitor 1, B7 family member H4, B7H4, B7-H4) and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], bispecific; H-gamma1 heavy chain

Common Name

English

RECOMBINANT BISPECIFIC HUMANISED IgG1 KAPPA ANTI-B7H4 MONOCLONAL ANTIBODY GEN1047 DS

Common Name

English

zubotamig [INN]

Common Name

English

Code System Code Type Description

CAS

2640279-10-1

Created by admin on Wed Apr 02 10:09:00 GMT 2025 , Edited by admin on Wed Apr 02 10:09:00 GMT 2025

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FDA UNII

99MWR4VJT2

Created by admin on Wed Apr 02 10:09:00 GMT 2025 , Edited by admin on Wed Apr 02 10:09:00 GMT 2025

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NCI_THESAURUS

C207024

Created by admin on Wed Apr 02 10:09:00 GMT 2025 , Edited by admin on Wed Apr 02 10:09:00 GMT 2025

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SMS_ID

300000012150

Created by admin on Wed Apr 02 10:09:00 GMT 2025 , Edited by admin on Wed Apr 02 10:09:00 GMT 2025

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INN

13007

Created by admin on Wed Apr 02 10:09:00 GMT 2025 , Edited by admin on Wed Apr 02 10:09:00 GMT 2025

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From	To
1_22	1_98
2_22	2_95
2_144	2_200
2_220	4_214
2_261	2_321
1_152	1_208
2_367	2_425
3_22	3_90
3_137	3_196
4_23	4_88
4_134	4_194
1_228	3_214
1_234	2_226
1_237	2_229
1_269	1_329
1_375	1_433

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_305
N	2_297

Related Record Type Details


					99MWR4VJT2

Zubotamig

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[2_1] [3_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL