Gallium-68 is a positron-emitting radioisotope that is produced from a 68Ge/68Ga generator. Gallium-68-labeled peptides have been recognized as a new class of radiopharmaceuticals showing fast target localization and blood clearance. Because of the convenient half-life of 68Ga and the fact that it is generator-produced and therefore more widely available, considerable interest lies in the development of 68Ga-labeled imaging agents. Dotatate gallium (Ga-68) is a somatostatin-2 receptor analog which is radiolabeled with gallium 68 as a positron-emitting radioisotope. Dotatate gallium 68 is one of the most prominent radiopharmaceuticals used in imaging with positron emission tomography. It binds to the somatostatin-2 receptor which is usually overexpressed in many neuroendocrine tumors in both adult and pediatric patients. Gallium-68 (Ga-68)-based tracers are easily available, relatively cost-effective, and have relative ease of labeling. Over the past few years, the development of Ga-68-based tracers has exploded with a recent growing interest in infection and inflammation imaging. An estimated ~10,000 scans are being performed yearly in Europe at about 100 centers utilizing 68Ga-labeled somatostatin analogs within clinical trials.