U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C18H21NS.BrH
Molecular Weight 364.343
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TEDATIOXETINE HYDROBROMIDE

SMILES

Br.CC1=CC=C(SC2=C(C=CC=C2)C3CCNCC3)C=C1

InChI

InChIKey=OJVYWXLMPZJYGV-UHFFFAOYSA-N
InChI=1S/C18H21NS.BrH/c1-14-6-8-16(9-7-14)20-18-5-3-2-4-17(18)15-10-12-19-13-11-15;/h2-9,15,19H,10-13H2,1H3;1H

HIDE SMILES / InChI

Molecular Formula C18H21NS
Molecular Weight 283.431
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula BrH
Molecular Weight 80.912
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Tedatioxetine (previously known as Lu AA24530) is a multimodal antidepressant that was developed for the treatment of depression and anxiety disorders (generalized anxiety disorder mainly). Tedatioxetine is a monoamine enhancer with reuptake inhibition at monoamine transporters and possesses an antagonist activity at 5-HT3 and 5-HT2c receptors. In 2009, the drug was studied in phase II clinical trials where it showed positive results in major depressive disorder. However, it remains unclear as to whether tedatioxetine development has been postponed and/or abandoned.

Approval Year

Sample Use Guides

Lu AA24530 (TEDATIOXETINE) 5 or 10 or 20 mg per oral, once daily for 6 weeks
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Dec 16 01:30:53 GMT 2023
Edited
by admin
on Sat Dec 16 01:30:53 GMT 2023
Record UNII
986RNR3CFM
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TEDATIOXETINE HYDROBROMIDE
USAN   WHO-DD  
USAN  
Official Name English
LU AA24530 (HBR)
Code English
Tedatioxetine hydrobromide [WHO-DD]
Common Name English
TEDATIOXETINE HYDROBROMIDE [USAN]
Common Name English
LU AA 24530 HYDROBROMIDE
Code English
PIPERIDINE, 4-(2-((4-METHYLPHENYL)THIO)PHENYL)-, HYDROBROMIDE (1:1)
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C265
Created by admin on Sat Dec 16 01:30:53 GMT 2023 , Edited by admin on Sat Dec 16 01:30:53 GMT 2023
Code System Code Type Description
SMS_ID
300000044505
Created by admin on Sat Dec 16 01:30:53 GMT 2023 , Edited by admin on Sat Dec 16 01:30:53 GMT 2023
PRIMARY
CAS
960151-65-9
Created by admin on Sat Dec 16 01:30:53 GMT 2023 , Edited by admin on Sat Dec 16 01:30:53 GMT 2023
PRIMARY
ChEMBL
CHEMBL2104986
Created by admin on Sat Dec 16 01:30:53 GMT 2023 , Edited by admin on Sat Dec 16 01:30:53 GMT 2023
PRIMARY
FDA UNII
986RNR3CFM
Created by admin on Sat Dec 16 01:30:53 GMT 2023 , Edited by admin on Sat Dec 16 01:30:53 GMT 2023
PRIMARY
PUBCHEM
24751582
Created by admin on Sat Dec 16 01:30:53 GMT 2023 , Edited by admin on Sat Dec 16 01:30:53 GMT 2023
PRIMARY
NCI_THESAURUS
C152536
Created by admin on Sat Dec 16 01:30:53 GMT 2023 , Edited by admin on Sat Dec 16 01:30:53 GMT 2023
PRIMARY
USAN
WW-42
Created by admin on Sat Dec 16 01:30:53 GMT 2023 , Edited by admin on Sat Dec 16 01:30:53 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY