TAPOTOCLAX

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C33H41ClN2O5S
Molecular Weight	613.207
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CO[C@H]1\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)C2=CC3=C(OC[C@]4(CCCC5=C4C=CC(Cl)=C5)CN3C[C@@H]6CC[C@@H]16)C=C2

InChI

InChIKey=JQNINBDKGLWYMU-GEAQBIRJSA-N

InChI=1S/C33H41ClN2O5S/c1-21-6-4-8-30(40-3)27-12-9-25(27)18-36-19-33(15-5-7-23-16-26(34)11-13-28(23)33)20-41-31-14-10-24(17-29(31)36)32(37)35-42(38,39)22(21)2/h4,8,10-11,13-14,16-17,21-22,25,27,30H,5-7,9,12,15,18-20H2,1-3H3,(H,35,37)/b8-4+/t21-,22+,25-,27+,30-,33-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C33H41ClN2O5S
Molecular Weight	613.207
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	6 / 6
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:17:58 GMT 2023` Edited by `admin` on `Sat Dec 16 10:17:58 GMT 2023`
Record UNII	97W7N9T08G
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

AMG-176

Preferred Name

English

TAPOTOCLAX

Official Name

English

SPIRO(5,7-ETHENO-1H,11H-CYCLOBUT(I)(1,4)OXAZEPINO(3,4- F)(1,2,7)THIADIAZACYCLOHEXADECINE-2(3H),1'(2'H)-NAPHTHALEN)-8(9H)-ONE, 6'-CHLORO-3',4',12,13,16,16A,17,18,18A,19-DECAHYDRO-16-METHOXY-11,12- DIMETHYL-, 10,10-DIOXIDE, (1'S,11R,12S,14E,16S,16AR,18AR)-

Systematic Name

English

MCL-1 INHIBITOR AMG-176

Common Name

English

TAPOTOCLAX [USAN]

Common Name

English

tapotoclax [INN]

Common Name

English

MCL-1 INHIBITOR AMG 176

Common Name

English

AMG176

Code

English

13S,31R,32R,4S,5E,8S,9R)-6'-CHLORO-4-METHOXY-8,9-DIMETHYL-3',4'-DIHYDRO-12H,14H,2'H-10.LAMBDA.6-THIA-11-AZASPIRO(1(5,7)-(1,5)BENZOXAZEPINA-3(1,2)-CYCLOBUTANACYCLODODECAPHAN-5-ENE-13,1'-NAPHTHALENE)-10,10,12-TRIONE

Systematic Name

English

AMG 176 [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C137990