RHODODENDROL, (-)-

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H14O2
Molecular Weight	166.217
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@H](O)CCC1=CC=C(O)C=C1

InChI

InChIKey=SFUCGABQOMYVJW-MRVPVSSYSA-N

InChI=1S/C10H14O2/c1-8(11)2-3-9-4-6-10(12)7-5-9/h4-8,11-12H,2-3H2,1H3/t8-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C10H14O2
Molecular Weight	166.217
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.trc-canada.com/product-detail/?R318655 | https://www.ncbi.nlm.nih.gov/pubmed/25130058

Racemic RS-4-(4-hydroxyphenyl)-2-butanol (rhododendrol, RD) was used as a topical skin-whitening agent until it was recently reported to induce leukoderma. (-)-Rhododendrol is its R(-)- enantiomer. (-)-Rhododendrol, can be extracted from the leaves of Abies webbiana Lindl., having dendrite elongation inhibition activity in cell lines.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Protein O-GlcNAcase 2 Target ID: CHEMBL3351213 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20363129	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
A perspective on the history of the academic health center.	1996 Sep	8822705
Human tyrosinase is able to oxidize both enantiomers of rhododendrol.	2014 Nov	25130058

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

(-)-Rhododendrol showed remarkable inhibitory effect on b-hexosaminidase activity at the concentration of 100 uM

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:27:16 GMT 2023` Edited by `admin` on `Sat Dec 16 01:27:16 GMT 2023`
Record UNII	97PTR2F3Z8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RHODODENDROL, (-)-

Common Name

English

BETULIGENOL, (-)-

Common Name

English

(R)-(-)-RHODODENDROL

Common Name

English

(-)-BETULIGENOL

Common Name

English

BENZENEPROPANOL, 4-HYDROXY-.ALPHA.-METHYL-, (R)-

Systematic Name

English

BENZENEPROPANOL, 4-HYDROXY-.ALPHA.-METHYL-, (.ALPHA.R)-

Common Name

English

(R)-FRAMBINOL

Common Name

English

BETULIGENOL

Common Name

English

2-BUTANOL, 4-(P-HYDROXYPHENYL)-

Common Name

English

Code System Code Type Description

WIKIPEDIA

Rhododendrol