RHODODENDROL, (-)-

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H14O2
Molecular Weight	166.217
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@H](O)CCC1=CC=C(O)C=C1

InChI

InChIKey=SFUCGABQOMYVJW-MRVPVSSYSA-N

InChI=1S/C10H14O2/c1-8(11)2-3-9-4-6-10(12)7-5-9/h4-8,11-12H,2-3H2,1H3/t8-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C10H14O2
Molecular Weight	166.217
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.trc-canada.com/product-detail/?R318655 | https://www.ncbi.nlm.nih.gov/pubmed/25130058

Racemic RS-4-(4-hydroxyphenyl)-2-butanol (rhododendrol, RD) was used as a topical skin-whitening agent until it was recently reported to induce leukoderma. (-)-Rhododendrol is its R(-)- enantiomer. (-)-Rhododendrol, can be extracted from the leaves of Abies webbiana Lindl., having dendrite elongation inhibition activity in cell lines.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Protein O-GlcNAcase 2 Target ID: CHEMBL3351213 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20363129	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Human tyrosinase is able to oxidize both enantiomers of rhododendrol.	2014-11	25130058
A perspective on the history of the academic health center.	1996-09	8822705

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

(-)-Rhododendrol showed remarkable inhibitory effect on b-hexosaminidase activity at the concentration of 100 uM

Substance Class	Chemical Created by `admin` on `Mon Mar 31 20:51:01 GMT 2025` Edited by `admin` on `Mon Mar 31 20:51:01 GMT 2025`
Record UNII	97PTR2F3Z8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

(-)-BETULIGENOL

Preferred Name

English

RHODODENDROL, (-)-

Common Name

English

BETULIGENOL, (-)-

Common Name

English

(R)-(-)-RHODODENDROL

Common Name

English

BENZENEPROPANOL, 4-HYDROXY-.ALPHA.-METHYL-, (R)-

Systematic Name

English

BENZENEPROPANOL, 4-HYDROXY-.ALPHA.-METHYL-, (.ALPHA.R)-

Common Name

English

(R)-FRAMBINOL

Common Name

English

BETULIGENOL

Common Name

English

2-BUTANOL, 4-(P-HYDROXYPHENYL)-

Common Name

English

Code System Code Type Description

WIKIPEDIA

Rhododendrol