TELISOTUZUMAB VEDOTIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Mon Mar 31 22:25:48 GMT 2025` Edited by `admin` on `Mon Mar 31 22:25:48 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	976X9VXC3Z
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

telisotuzumab vedotin [INN]

Preferred Name

English

TELISOTUZUMAB VEDOTIN

Official Name

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN HEPATOCYTE GROWTH FACTOR RECEPTOR) (HUMAN-MUS MUSCULUS MONOCLONAL ABT-700 HEAVY CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL ABT-700 .KAPPA.-CHAIN, DIMER, THIOETHER WITH N-(((4-((N-(6-(3-MERCAPTO-2,5-DIOXO-1-PYRROLI

Systematic Name

English

PR-1420682

Code

English

ABT-700-VCMMAE

Common Name

English

ABBV-399

Common Name

English

TELISOTUZUMAB VEDOTIN [USAN]

Common Name

English

Telisotuzumab vedotin [WHO-DD]

Common Name

English

ABT-399

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C1512

Created by admin on Mon Mar 31 22:25:48 GMT 2025 , Edited by admin on Mon Mar 31 22:25:48 GMT 2025

NCI_THESAURUS

C129823

Created by admin on Mon Mar 31 22:25:48 GMT 2025 , Edited by admin on Mon Mar 31 22:25:48 GMT 2025

NCI_THESAURUS

C20401

Created by admin on Mon Mar 31 22:25:48 GMT 2025 , Edited by admin on Mon Mar 31 22:25:48 GMT 2025

Code System Code Type Description

SMS_ID

100000174225

Created by admin on Mon Mar 31 22:25:48 GMT 2025 , Edited by admin on Mon Mar 31 22:25:48 GMT 2025

PRIMARY

INN

10365

Created by admin on Mon Mar 31 22:25:48 GMT 2025 , Edited by admin on Mon Mar 31 22:25:48 GMT 2025

PRIMARY

CAS

1714088-51-3

Created by admin on Mon Mar 31 22:25:48 GMT 2025 , Edited by admin on Mon Mar 31 22:25:48 GMT 2025

PRIMARY

USAN

EF-53

Created by admin on Mon Mar 31 22:25:48 GMT 2025 , Edited by admin on Mon Mar 31 22:25:48 GMT 2025

PRIMARY

FDA UNII

976X9VXC3Z

Created by admin on Mon Mar 31 22:25:48 GMT 2025 , Edited by admin on Mon Mar 31 22:25:48 GMT 2025

PRIMARY

NCI_THESAURUS

C118571

Created by admin on Mon Mar 31 22:25:48 GMT 2025 , Edited by admin on Mon Mar 31 22:25:48 GMT 2025

PRIMARY

DRUG BANK

DB15104

Created by admin on Mon Mar 31 22:25:48 GMT 2025 , Edited by admin on Mon Mar 31 22:25:48 GMT 2025

PRIMARY

From	To
1_22	1_96
1_145	1_201
1_260	1_320
1_366	1_424
2_22	2_96
2_145	2_201
2_260	2_320
2_366	2_424
3_23	3_92
3_138	3_198
4_23	4_92
4_138	4_198
1_221	3_218
2_221	4_218
1_223	2_223
1_225	2_225
1_228	2_228

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_296
N	2_296

Related Record Type Details


					R15ZW356HN

PARENT -> CONJUGATE

Amount:


					QA085PMU8Q

HEPATOCYTE GROWTH FACTOR RECEPTOR

TARGET -> INHIBITOR

Interaction Type:

BINDING

Amount:


					Q3606FDE0B

VEDOTIN FRAGMENT

TOXIN -> CONJUGATE

Amount:

Related Record Type Details


					976X9VXC3Z

TELISOTUZUMAB VEDOTIN

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_221] [1_223] [1_225] [1_228] [2_221] [2_223] [2_225] [2_228] [3_218] [4_218]		CYSTEINE	Amount:	Cysteinyl vedotin	6603L01WUR

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:ESTIMATE	CHEMICAL