Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C17H17ClN2O |
| Molecular Weight | 300.783 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCNC1=NC2=C(C=C(Cl)C=C2)[C@@](C)(O1)C3=CC=CC=C3
InChI
InChIKey=IBYCYJFUEJQSMK-KRWDZBQOSA-N
InChI=1S/C17H17ClN2O/c1-3-19-16-20-15-10-9-13(18)11-14(15)17(2,21-16)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3,(H,19,20)/t17-/m0/s1
| Molecular Formula | C17H17ClN2O |
| Molecular Weight | 300.783 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.google.com/patents/WO2016154039A1
Sources: https://www.google.com/patents/WO2016154039A1
(S)-Etifoxine is a first in class pain-relieving drug candidate, with the power of morphine and oxycodone, but without the addictive, sedative and GI side effects. (S)-etifoxine is an isomer, chemically isolated from Etifoxine (Stresam), an approved racemic drug (off patent) prescribed in Europe. Preclinical studies determined that the (S)-isomer of Stresam® ((S)-etifoxine) is a non-sedating anxiolytic. It was also discovered that (S)-etifoxine possesses highly potent analgesic activity comparable to morphine (the gold standard) which is consistent with Stresam®’s TSPO-mediated effects on chemotherapy-induced neuropathy and peripheral nerve injury. However, (S)-etifoxine does not display any of the negative side-effects associated with morphine. Even more notably, Stresam® has demonstrated peripheral nerve regeneration and functional recovery. It is believed that (S)-etifoxine will retain these same properties.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25589941
Curator's Comment: Data for R/S-Etifoxine
Originator
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16625522
50 mg tid as etifoxine
Route of Administration:
Oral
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:55:05 GMT 2025
by
admin
on
Mon Mar 31 22:55:05 GMT 2025
|
| Record UNII |
963E1X3T2S
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Preferred Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
950513-31-2
Created by
admin on Mon Mar 31 22:55:06 GMT 2025 , Edited by admin on Mon Mar 31 22:55:06 GMT 2025
|
PRIMARY | |||
|
135564604
Created by
admin on Mon Mar 31 22:55:06 GMT 2025 , Edited by admin on Mon Mar 31 22:55:06 GMT 2025
|
PRIMARY | |||
|
963E1X3T2S
Created by
admin on Mon Mar 31 22:55:06 GMT 2025 , Edited by admin on Mon Mar 31 22:55:06 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
RACEMATE -> ENANTIOMER |