Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C17H17ClN2O |
Molecular Weight | 300.783 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCNC1=NC2=CC=C(Cl)C=C2[C@@](C)(O1)C3=CC=CC=C3
InChI
InChIKey=IBYCYJFUEJQSMK-KRWDZBQOSA-N
InChI=1S/C17H17ClN2O/c1-3-19-16-20-15-10-9-13(18)11-14(15)17(2,21-16)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3,(H,19,20)/t17-/m0/s1
Molecular Formula | C17H17ClN2O |
Molecular Weight | 300.783 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.google.com/patents/WO2016154039A1
Sources: https://www.google.com/patents/WO2016154039A1
(S)-Etifoxine is a first in class pain-relieving drug candidate, with the power of morphine and oxycodone, but without the addictive, sedative and GI side effects. (S)-etifoxine is an isomer, chemically isolated from Etifoxine (Stresam), an approved racemic drug (off patent) prescribed in Europe. Preclinical studies determined that the (S)-isomer of Stresam® ((S)-etifoxine) is a non-sedating anxiolytic. It was also discovered that (S)-etifoxine possesses highly potent analgesic activity comparable to morphine (the gold standard) which is consistent with Stresam®’s TSPO-mediated effects on chemotherapy-induced neuropathy and peripheral nerve injury. However, (S)-etifoxine does not display any of the negative side-effects associated with morphine. Even more notably, Stresam® has demonstrated peripheral nerve regeneration and functional recovery. It is believed that (S)-etifoxine will retain these same properties.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25589941
Curator's Comment: Data for R/S-Etifoxine
Originator
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16625522
50 mg tid as etifoxine
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:55:26 GMT 2023
by
admin
on
Sat Dec 16 09:55:26 GMT 2023
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Record UNII |
963E1X3T2S
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Record Status |
Validated (UNII)
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Record Version |
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135564604
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963E1X3T2S
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admin on Sat Dec 16 09:55:26 GMT 2023 , Edited by admin on Sat Dec 16 09:55:26 GMT 2023
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Related Record | Type | Details | ||
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RACEMATE -> ENANTIOMER |