SERAZAPINE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C22H23N3O2.ClH
Molecular Weight	397.898
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.COC(=O)C1=C2C3CN(C)CCN3C4=CC=CC=C4CN2C5=C1C=CC=C5

InChI

InChIKey=YEITZTKANLXOTH-UHFFFAOYSA-N

InChI=1S/C22H23N3O2.ClH/c1-23-11-12-24-17-9-5-3-7-15(17)13-25-18-10-6-4-8-16(18)20(22(26)27-2)21(25)19(24)14-23;/h3-10,19H,11-14H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C22H23N3O2
Molecular Weight	361.4369
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8104044 | https://books.google.ca/books?id=xUlaDwAAQBAJ&pg=PT1178&lpg=PT1178&dq=SERAZAPINE+drug&source=bl&ots=CnAWmMiDbV&sig=ACfU3U33B6BN8vFXW-6o9p_Cau5-MUiRKQ&hl=en&sa=X&ved=2ahUKEwjfjuC2i4njAhVJaM0KHQhkCbQQ6AEwCnoECAkQAQ#v=onepage&q=SERAZAPINE%20drug&f=false retrieved from Drugs: Synonyms and Properties: Synonyms and Properties edited by George W.A Milne

Serazapine (CGS15040) is an anxiolytic agent. It is structurally novel 5-HT2 receptor antagonist. Preliminary preclinical findings indicated an anticonflict effect in a behavioral suppression test, and two preliminary investigations in volunteers also suggested anxiolytic potential. In the first of these studies serazapine resembled diazepam, a reference anxiolytic drug, electroencephalographically. Additionally, in a test of psychogenic stress in volunteers it reduced cardiac output.

Originator

Approval Year

PubMed

Title	Date	PubMed
Determination of CGS 15040A in human plasma by liquid chromatography.	1991	1680469
Serotonergic (5-HT2) mediation of anxiety-therapeutic effects of serazepine in generalized anxiety disorder.	1993 Jul 1-15	8104044

Patents

Sample Use Guides

In Vivo Use Guide

A double-blind, randomized, placebo-controlled four-compartment parallel group, multicenter trial in outpatients with Generalized Anxiety Disorder (GAD): a 14-to 30-day drug-free interval preceded study entry. For all qualified patients, a 1-week, single-blind placebo washout period was followed by a 5-week, double-blind treatment phase involving a once daily oral dose of either 10 mg, 20 mg, or 40 mg of Serazapine (CGS15040), or placebo. The 40-mg group tended to perform better (larger decreases from baseline in the total Ham-A score) than the other groups.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:14:00 GMT 2023` Edited by `admin` on `Fri Dec 15 15:14:00 GMT 2023`
Record UNII	962IFR72N1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SERAZAPINE HYDROCHLORIDE

Official Name

English

2H,10H-INDOLO(2,1-C)PYRAZINO(1,2-A)(1,4)BENZODIAZEPINE-16-CARBOXYLIC ACID, 1,3,4,16B-TETRAHYDRO-2-METHYL-, METHYL ESTER, MONOHYDROCHLORIDE

Common Name

English

CGS-15040A

Code

English

2H,10H-INDOLO(2,1-C)PYRAZINO(1,2-A)(1,4)BENZODIAZEPINE-16-CARBOXYLIC ACID, 1,3,4,16B-TETRAHYDRO-2-METHYL-, METHYL ESTER, HYDROCHLORIDE (1:1)

Systematic Name

English

SERAZAPINE HYDROCHLORIDE [USAN]

Common Name

English

Serazapine hydrochloride [WHO-DD]

Common Name

English

CGS 15040A

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C28197