Stereochemistry | RACEMIC |
Molecular Formula | C7H6O4 |
Molecular Weight | 154.1201 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1OCC=C2OC(=O)C=C12
InChI
InChIKey=ZRWPUFFVAOMMNM-UHFFFAOYSA-N
InChI=1S/C7H6O4/c8-6-3-4-5(11-6)1-2-10-7(4)9/h1,3,7,9H,2H2
Molecular Formula | C7H6O4 |
Molecular Weight | 154.1201 |
Charge | 0 |
Count |
MOL RATIO
1 MOL RATIO (average) |
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Patulin is a toxic secondary metabolite produced by molds, especially Penicillium and Aspergillus, and is usually found in apples and apple-derived products including juice and compote. Several reports have demonstrated that exposure to different levels of this polyketide metabolite is associated with immunotoxicity, genotoxicity, embryotoxicity, and teratogenicity in animals and some microorganisms. Recently was shown, that patulin possesses the antitumor activity against cervical and colorectal cancer cell lines.
Approval Year
PubMed
Sample Use Guides
risk assessment of patulin occurrence in fruit juices: revealed no health concern.
Route of Administration:
Oral
To determine the efficacy of patulin as a therapeutic strategy for cervical and colorectal cancers, there were investigated its effects on HeLa,SW-48, and MRC-5 cell lines. Cell lines were exposed to various concentrations of patulin (i.e., 0.5, 1, 2, and 4 µM), then using methyl thiazolyl tetrazolium (MTT) and bromo-2'-deoxyuridine (BrdU) assays, the rates of apoptosis and cell viability were determined.