Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C5H12N2 |
| Molecular Weight | 100.1622 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C1CNCCNC1
InChI
InChIKey=FQUYSHZXSKYCSY-UHFFFAOYSA-N
InChI=1S/C5H12N2/c1-2-6-4-5-7-3-1/h6-7H,1-5H2
| Molecular Formula | C5H12N2 |
| Molecular Weight | 100.1622 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A series of Cu(II)-azide polymers of Cu6 building units and the role of chelating diamine in controlling their dimensionality: synthesis, structures, and magnetic behavior. | 2010-11-15 |
|
| Bis(homopiperazine-1,4-diium) cyclo-tetra-phosphate-telluric acid (1/2). | 2010-10-02 |
|
| Synthesis of 2-(4-substituted benzyl-1,4-diazepan-1-yl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-7-yl)acetamides and their positive inotropic evaluation. | 2010-08-01 |
|
| Synthesis of a histamine H(3) receptor antagonist-manipulation of hydroxyproline stereochemistry, desymmetrization of homopiperazine, and nonextractive sodium triacetoxyborohydride reaction workup. | 2010-07-02 |
|
| Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers. | 2010-05-01 |
|
| Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists. | 2010-04-01 |
|
| Tertiary skipped diynes: a pluripotent building block for the modular and diversity-oriented synthesis of nitrogen heterocycles. | 2010-03-15 |
|
| A series of peroxomanganese(III) complexes supported by tetradentate aminopyridyl ligands: detailed spectroscopic and computational studies. | 2010-03-03 |
|
| Dramatic increase of selectivity for heavy lanthanide(III) cations by tuning the flexibility of polydentate chelators. | 2010-01-18 |
|
| Synthesis and evaluation of (S,S)-N,N'-bis-[3-(2,2',6,6'-tetramethylbenzhydryloxy)-2-hydroxy-propyl]-ethylenediamine (S2824) analogs with anti-tuberculosis activity. | 2009-11-01 |
|
| Expedite protocol for construction of chiral regioselectively N-protected monosubstituted piperazine, 1,4-diazepane, and 1,4-diazocane building blocks. | 2009-08-07 |
|
| Synthesis of dimeric quinazolin-2-one, 1,4-benzodiazepin-2-one, and isoalloxazine compounds as inhibitors of amyloid peptides association. | 2009-08 |
|
| Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in rats. | 2009-07 |
|
| Synthesis and evaluation of piperazine and homopiperazine analogues of JS-K, an anti-cancer lead compound. | 2009-05-15 |
|
| User-friendly stereoselective one-pot access to 1,4-diazepane derivatives by a cyclodehydrative three-component reaction with 1,3-dicarbonyls. | 2009-05-07 |
|
| 1,4-Diazepanes derived from (S)-serine--homopiperazines with improved sigma(1) (sigma) receptor affinity and selectivity. | 2009-02 |
|
| Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors. | 2008-12-15 |
|
| Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs. | 2008-11-15 |
|
| Novel C-5 aminomethyl pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases. | 2007-05-15 |
|
| N, N -disubstituted piperazines and homopiperazines: synthesis and affinities at alpha4beta2* and alpha7* neuronal nicotinic acetylcholine receptors. | 2006-12 |
|
| Identification of new diamine scaffolds with activity against Mycobacterium tuberculosis. | 2006-06-01 |
|
| Docking of 6-chloropyridazin-3-yl derivatives active on nicotinic acetylcholine receptors into molluscan acetylcholine binding protein (AChBP). | 2005-04 |
|
| [High throughput screening of pharmacokinetics and metabolism in drug discovery (II)--investigation on in vitro and in vivo correlation in drug metabolism screening]. | 2005-01 |
|
| Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives. | 2004-11-01 |
|
| Orally active factor Xa inhibitor: synthesis and biological activity of masked amidines as prodrugs of novel 1,4-diazepane derivatives. | 2004-10-15 |
|
| Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity. | 2004-05-01 |
|
| Exploration of composition space in templated uranium sulfates. | 2003-11-03 |
|
| A new class of spermidine-derived alkaloids. | 2003-08-07 |
|
| Trypanocidal activity of conformationally restricted pentamidine congeners. | 2003-03-13 |
|
| Potent and selective inhibitors of PDGF receptor phosphorylation. 2. Synthesis, structure activity relationship, improvement of aqueous solubility, and biological effects of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives. | 2002-09-26 |
|
| 6-Chloropyridazin-3-yl derivatives active as nicotinic agents: synthesis, binding, and modeling studies. | 2002-08-29 |
|
| New mu-opioid receptor agonists with piperazine moiety. | 2001-10 |
|
| Subtle bite-angle influences on N(2)S(2)Ni complexes. | 2001-07-02 |
|
| Steric control of stereoselective interactions between the platinum(II) complex [PtCl2(1,4-diazacycloheptane)] and DNA: comparison with cis-[PtCl2(NH3)2] and [PtCl2(ethane-1,2-diamine)] using DNA binding and molecular modeling studies. | 2001-06 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:58:24 GMT 2025
by
admin
on
Mon Mar 31 19:58:24 GMT 2025
|
| Record UNII |
95CL167W8T
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| Record Status |
Validated (UNII)
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| Record Version |
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68163
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1,4-Diazacycloheptane
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DTXSID1060130
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95CL167W8T
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505-66-8
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208-016-1
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