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INOTERSEN SODIUM
950736UC77
US Previously Marketed
First approved in 2018
General
Record Details
Names
9
Classification
1
Identifiers
10
Subunits
1
Sugars
2
Linkages
1
Relationships
1
Active Moiety
1
Modifications
3
INOTERSEN SODIUM
950736UC77
US Previously Marketed
First approved in 2018
General
Approval Year
2018
436
Record Details
Substance Class
Nucleic Acid
Nucleic Acid Type
OLIGONUCLEOTIDE
Nucleic Acid Subtype
Record UNII
950736UC77
Record Status
Validated (UNII)
Record Version
22
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Names
9
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entries
Name
Type
Language
Name
Type
Language
INOTERSEN SODIUM
Official Name
English
INOTERSEN SODIUM [ORANGE BOOK]
Common Name
English
ISIS-420915 SODIUM SALT
Code
English
INOTERSEN SODIUM [USAN]
Common Name
English
TEGSEDI
Brand Name
English
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Classification
1
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Classification Tree
Code System
Code
Classification Tree
Code System
Code
Positive
EU ORPHAN DRUG
Positive
Treatment of ATTR amyloidosis
EU-Orphan Drug
EU/3/14/1250
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Identifiers
10
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Code System
Code
Type
Description
Code System
Code
Type
Description
CAS
1432726-13-0
PRIMARY
EPA CompTox
DTXSID801027904
PRIMARY
FDA UNII
950736UC77
PRIMARY
RXCUI
2099290
PRIMARY
DAILYMED
950736UC77
PRIMARY
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Subunits
1
Subunit 0
>SUBUNIT_0
Sugars
2
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Sugar
Site Range
Site Count
Sugar
Site Range
Site Count
Deoxyribose (DNA)
1_6-1_15
10 / 20
2-O-beta-hydroxy-ethoxy-methyl Ribose (Qiagen)
1_1-1_5;1_16-1_20
10 / 20
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Linkages
1
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Linkage
Site Range
Site Count
Linkage
Site Range
Site Count
Sodium Phosporothioate
1_2-1_20
19 / 19
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Relationships
1
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entries
Related Record
Type
Details
Related Record
Type
Details
0IEO0F56LV
INOTERSEN
PARENT -> SALT/SOLVATE
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Active Moiety
1
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Related Record
Type
Details
Related Record
Type
Details
0IEO0F56LV
INOTERSEN
ACTIVE MOIETY
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Modifications
3
Structural Modifications
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entries
Modification Type
Location Site
Location Type
Residue Modified
Extent
Fragment Name
Fragment Approval
Modification Type
Location Site
Location Type
Residue Modified
Extent
Fragment Name
Fragment Approval
NUCLEOSIDE_SUBSTITUTION
[1_10]
SITE_SPECIFIC
5-METHYLDEOXYCYTIDINE
B200GV71QM
NUCLEOSIDE_SUBSTITUTION
[1_1] [1_3] [1_4] [1_17]
SITE_SPECIFIC
2'-O-(2-METHOXYETHYL)-5-METHYLURIDINE
9Q36I4D9VB
NUCLEOSIDE_SUBSTITUTION
[1_2] [1_18] [1_19] [1_20]
SITE_SPECIFIC
2'-O-(2-METHOXYETHYL)-5-METHYLCYTIDINE
AOQ54IZZ6J
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