Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H16Cl4N2O4S4 |
| Molecular Weight | 570.381 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC=C(Cl)C(=C1)S(=O)(=O)NCCSSCCNS(=O)(=O)C2=CC(Cl)=CC=C2Cl
InChI
InChIKey=REQLACDIZMLXIC-UHFFFAOYSA-N
InChI=1S/C16H16Cl4N2O4S4/c17-11-1-3-13(19)15(9-11)29(23,24)21-5-7-27-28-8-6-22-30(25,26)16-10-12(18)2-4-14(16)20/h1-4,9-10,21-22H,5-8H2
| Molecular Formula | C16H16Cl4N2O4S4 |
| Molecular Weight | 570.381 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Inhibiting the hypoxia response for cancer therapy: the new kid on the block. | 2009 Oct 1 |
|
| Identification of a novel small molecule HIF-1alpha translation inhibitor. | 2009 Oct 1 |
|
| HIF-1α contributes to hypoxia adaptation of the naked mole rat. | 2017 Dec 15 |
|
| FG-4592 Accelerates Cutaneous Wound Healing by Epidermal Stem Cell Activation via HIF-1α Stabilization. | 2018 |
|
| The role of HIF-1α in the TGF-β2-mediated epithelial-to-mesenchymal transition of human lens epithelial cells. | 2018 Aug |
|
| LincRNA-p21 promotes mesenchymal stem cell migration capacity and survival through hypoxic preconditioning. | 2018 Oct 25 |
|
| Chitin synthesis inhibitors promote liver cancer cell metastasis via interfering with hypoxia-inducible factor 1α. | 2018 Sep |
|
| Melatonin restricts the viability and angiogenesis of vascular endothelial cells by suppressing HIF-1α/ROS/VEGF. | 2019 Feb |
|
| Ginsenoside Rg1 inhibits myocardial ischaemia and reperfusion injury via HIF-1 α-ERK signalling pathways in a diabetic rat model. | 2019 Mar 1 |
|
| Salidroside ameliorated hypoxia-induced tumorigenesis of BxPC-3 cells via downregulating hypoxia-inducible factor (HIF)-1α and LOXL2. | 2020 Jan |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 18:10:47 GMT 2023
by
admin
on
Sat Dec 16 18:10:47 GMT 2023
|
| Record UNII |
94C2DMM81L
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
16047442
Created by
admin on Sat Dec 16 18:10:47 GMT 2023 , Edited by admin on Sat Dec 16 18:10:47 GMT 2023
|
PRIMARY | |||
|
927822-86-4
Created by
admin on Sat Dec 16 18:10:47 GMT 2023 , Edited by admin on Sat Dec 16 18:10:47 GMT 2023
|
PRIMARY | |||
|
94C2DMM81L
Created by
admin on Sat Dec 16 18:10:47 GMT 2023 , Edited by admin on Sat Dec 16 18:10:47 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
