KC7F2

ClC1=CC=C(Cl)C(=C1)S(=O)(=O)NCCSSCCNS(=O)(=O)C2=CC(Cl)=CC=C2Cl

InChIKey=REQLACDIZMLXIC-UHFFFAOYSA-N

InChI=1S/C16H16Cl4N2O4S4/c17-11-1-3-13(19)15(9-11)29(23,24)21-5-7-27-28-8-6-22-30(25,26)16-10-12(18)2-4-14(16)20/h1-4,9-10,21-22H,5-8H2

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Hypoxia-inducible factor 1 alpha 17 Target ID: CHEMBL4261 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19789328	Inhibitor 8297		20.0 µM [IC50]
Hypoxia-inducible factor 1 alpha 17 Target ID: CHEMBL4261 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19789328	Inhibitor 8297		20.0 µM [IC50]

PubMed

Title	Date	PubMed
Identification of a novel small molecule HIF-1alpha translation inhibitor.	2009 Oct 1	19789328
HIF-1α contributes to hypoxia adaptation of the naked mole rat.	2017 Dec 15	29299120
The role of HIF-1α in the TGF-β2-mediated epithelial-to-mesenchymal transition of human lens epithelial cells.	2018 Aug	29693273

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:10:47 GMT 2023` Edited by `admin` on `Sat Dec 16 18:10:47 GMT 2023`
Record UNII	94C2DMM81L
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

KC7F2

Common Name

English

N,N'-(DITHIODI-2,1-ETHANEDIYL)BIS(2,5-DICHLOROBENZENESULFONAMIDE)

Systematic Name

English

Code System Code Type Description

PUBCHEM

16047442

Created by admin on Sat Dec 16 18:10:47 GMT 2023 , Edited by admin on Sat Dec 16 18:10:47 GMT 2023

PRIMARY

CAS

927822-86-4

Created by admin on Sat Dec 16 18:10:47 GMT 2023 , Edited by admin on Sat Dec 16 18:10:47 GMT 2023

PRIMARY

FDA UNII

94C2DMM81L

Created by admin on Sat Dec 16 18:10:47 GMT 2023 , Edited by admin on Sat Dec 16 18:10:47 GMT 2023

PRIMARY

Related Record Type Details


					94C2DMM81L

KC7F2

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