U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 18:34:20 GMT 2023
Edited
by admin
on Sat Dec 16 18:34:20 GMT 2023
Source Materials Class ORGANISM
Source Materials Type RECOMBINANT VIRUS
Source Materials State LIVE NON-REPLICATING GENETICALLY MODIFIED
Organism Family Adenoviridae
Organism Genus Mastadenovirus
Organism Species human mastadenovirus c
Infraspecific Type SUBSTRAIN
Infraspecific Name AD5-(DELETED E1/E3)CMV- VEGF exons 1-5 (partial cDNA), exon 6 (splice modified), exon 7,8- SV40
Part whole
Record UNII
93TLW455ZZ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ENCOBERMINOGENE REZMADENOVEC
USAN   INN  
Official Name English
A REPLICATION-DEFICIENT RECOMBINANT ADENOVIRUS, SEROTYPE 5, ENCODING MULTIPLE HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) ISOFORMS
Common Name English
encoberminogene rezmadenovec [INN]
Common Name English
XC-001
Code English
XC001
Code English
ENCOBERMINOGENE REZMADENOVEC [USAN]
Common Name English
DNA (SYNTHETIC HUMAN ADENOVIRUS 5 VECTOR XC001 HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR-SPECIFYING)
Common Name English
A REPLICATION-DEFICIENT RECOMBINANT ADENOVIRUS, SEROTYPE 5 (AD5), ENCODING MULTIPLE HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) ISOFORMS (VEGF121, VEGF165 AND VEGF189) UNDER THE CONTROL OF A CYTOMEGALOVIRUS IMMEDIATE EARLY PROMOTER/ENHANCER (CMV) AND
Common Name English
Code System Code Type Description
USAN
KL-13
Created by admin on Sat Dec 16 18:34:20 GMT 2023 , Edited by admin on Sat Dec 16 18:34:20 GMT 2023
PRIMARY
INN
11543
Created by admin on Sat Dec 16 18:34:20 GMT 2023 , Edited by admin on Sat Dec 16 18:34:20 GMT 2023
PRIMARY INN
NCI_THESAURUS
C179083
Created by admin on Sat Dec 16 18:34:20 GMT 2023 , Edited by admin on Sat Dec 16 18:34:20 GMT 2023
PRIMARY
CAS
2376853-01-7
Created by admin on Sat Dec 16 18:34:20 GMT 2023 , Edited by admin on Sat Dec 16 18:34:20 GMT 2023
PRIMARY
FDA UNII
93TLW455ZZ
Created by admin on Sat Dec 16 18:34:20 GMT 2023 , Edited by admin on Sat Dec 16 18:34:20 GMT 2023
PRIMARY
Related Record Type Details
EXPRESSED PROTEIN->VECTOR
EXPRESSED PROTEIN->VECTOR
EXPRESSED PROTEIN->VECTOR
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
INSERTED GENE EXPRESSION VECTOR UNSPECIFIED SUBSTANCE
706cc23d
(not in database)
PROTEIN NOT EXPRESSED (GENE DISRUPTION) EARLY E1A PROTEIN (HUMAN ADENOVIRUS 5) MW6YY4WVP4
GENE DELETION ADENOVIRUS 5 E3 GENE A62MKE7J2U