Tobemstomig

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 13:24:00 GMT 2025` Edited by `admin` on `Wed Apr 02 13:24:00 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	93NRF4S9HR
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

RO-7247669

Preferred Name

English

Tobemstomig

Official Name

English

RG6139

Code

English

TOBEMSTOMIG [USAN]

Common Name

English

Tobemstomig [WHO-DD]

Common Name

English

tobemstomig [INN]

Common Name

English

PD1-LAG3 BSAB (RO-7247669)

Code

English

RO7247669

Code

English

Immunoglobulin G1 [151-glutamic acid,217-glutamic acid,236-alanine,237-alanine,331-glycine,351-cysteine,368-serine,370-alanine,409-valine], anti-(human lymphocyte activation gene-3 protein) (human-Oryctolagus cuniculus monoclonal LAG3-0414 ?1-chain), dis

Common Name

English

immunoglobulin G1-kappa with crossed domains, anti-[Homo sapiens PDCD1 (programmed cell death 1, PD1, PD-1, CD279)] and anti-[Homo sapiens LAG3 (lymphocyte activating 3, lymphocyte-activation 3, CD223)], humanized monoclonal antibody, bispecific

Common Name

English

RG-6139

Code

English

PD1/LAG3 (RO-7247669)

Code

English

PD1-LAG3 (RO-7247669)

Code

English

Anti-PD1/Anti-LAG3 Bispecific Antibody RO7247669

Code

English

Code System Code Type Description

USAN

MN-153

Created by admin on Wed Apr 02 13:24:00 GMT 2025 , Edited by admin on Wed Apr 02 13:24:00 GMT 2025

PRIMARY

SMS_ID

300000043600

Created by admin on Wed Apr 02 13:24:00 GMT 2025 , Edited by admin on Wed Apr 02 13:24:00 GMT 2025

PRIMARY

NCI_THESAURUS

C173539

Created by admin on Wed Apr 02 13:24:00 GMT 2025 , Edited by admin on Wed Apr 02 13:24:00 GMT 2025

PRIMARY

FDA UNII

93NRF4S9HR

Created by admin on Wed Apr 02 13:24:00 GMT 2025 , Edited by admin on Wed Apr 02 13:24:00 GMT 2025

PRIMARY

INN

12318

Created by admin on Wed Apr 02 13:24:00 GMT 2025 , Edited by admin on Wed Apr 02 13:24:00 GMT 2025

PRIMARY

CAS

2648839-43-2

Created by admin on Wed Apr 02 13:24:00 GMT 2025 , Edited by admin on Wed Apr 02 13:24:00 GMT 2025

PRIMARY

CAS

2640186-09-8

Created by admin on Wed Apr 02 13:24:00 GMT 2025 , Edited by admin on Wed Apr 02 13:24:00 GMT 2025

NO STRUCTURE GIVEN

From	To
4_134	4_194
4_23	4_88
3_147	3_207
3_22	3_96
2_363	2_421
2_257	2_317
2_216	3_227
2_140	2_196
2_23	2_92
1_353	2_350
1_371	1_429
1_265	1_325
1_233	2_225
1_230	2_222
1_224	4_214
1_148	1_204
1_22	1_96

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_301
N	2_293

Related Record Type Details


					P050J5FWC5

INTERFERON GAMMA

TARGET->ACTIVATOR OF EXPRESSION

Amount:


					AK0JDV1ZK5

LYMPHOCYTE ACTIVATION GENE 3 PROTEIN

TARGET->LIGAND

Amount:


					2OIM6T84W1

TARGET->ACTIVATOR OF EXPRESSION

Amount:


					938DNF64FO

PROGRAMMED CELL DEATH PROTEIN 1

TARGET->LIGAND

Amount:

Related Record Type Details


					93NRF4S9HR

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_451] [2_443]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL